Details for Patent: 4,559,332
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Summary for Patent: 4,559,332
| Title: | 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof |
| Abstract: | Steroid compounds of the 20-spiroxane series and their analogues having an open ring E of the formula, ##STR1## in which --A--A-- represents the group --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, R.sup.1 represents hydrogen, and R.sup.2 represents an .alpha.-oriented lower alkoxycarbonyl radical, or R.sup.1 and R.sup.2 together represent an .alpha.- or a .beta.-oriented methylene radical, --B--B-- represents the group --CH.sub.2 --CH.sub.2 -- or an .alpha.- or .beta.-oriented group ##STR2## X represents two hydrogen atoms or oxo, Y.sup.1 and Y.sup.2 together represent the oxygen bridge --O--, or Y.sup.1 represents hydroxy, and Y.sup.2 represents hydroxy, lower alkoxy or, if X represents H.sub.2, also lower alkanoyloxy, and salts of compounds in which X represents oxo and Y.sup.2 represents hydroxy, are distinguished as effective aldosterone-antagonists with minimal side-effects and, for that reason, are especially suitable for the treatment of all forms of hyperaldosteronism. |
| Inventor(s): | Grob; Jurgen (Giebenach, CH), Kalvoda; Jaroslav (Binningen, CH) |
| Assignee: | Ciba Geigy Corporation (Ardsley, NY) |
| Application Number: | 06/598,109 |
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Patent Claim Types: see list of patent claims | Compound; Composition; Use; |
Drugs Protected by US Patent 4,559,332
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 4,559,332
| Foriegn Application Priority Data | ||
| Foreign Country | Foreign Patent Number | Foreign Patent Date |
| Switzerland | 1981/83 | Apr 13, 1983 |
International Family Members for US Patent 4,559,332
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| European Patent Office | 0122232 | ⤷ Sign Up | 300144 | Netherlands | ⤷ Sign Up |
| European Patent Office | 0122232 | ⤷ Sign Up | 91072 | Luxembourg | ⤷ Sign Up |
| European Patent Office | 0122232 | ⤷ Sign Up | 2004C/008 | Belgium | ⤷ Sign Up |
| Argentina | 241918 | ⤷ Sign Up | |||
| Argentina | 242221 | ⤷ Sign Up | |||
| Argentina | 242222 | ⤷ Sign Up | |||
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
