Details for Patent: 4,933,360

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Summary for Patent: 4,933,360

Title:	Novel chlorthalidone process and product
Abstract:	Water-soluble dispersions of chlorthalidone are prepared by a process comprising: (a) forming a solution comprising a water soluble pharmaceutically acceptable polymeric carrier and a C.sub.1 -C.sub.4 alkanol, (b) dissolving chlorthalidone in the solution thus formed, and (c) removing the C.sub.1 -C.sub.4 alkanol from the solution by evaporation, the amount of said carrier being effective to suppress substantially the formation of the alkyl ether by-product from the reaction of chlorthalidone with the C.sub.1 -C.sub.4 alkanol. A preferred water soluble carrier is polyvinylpyrrolidone and a preferred C.sub.1 -C.sub.4 alkanol is methanol.
Inventor(s):	Pandit; Nivedita (Middlebury, CT), Horhota; Stephen T. (Brookfield, CT)
Assignee:	Boehringer Ingelheim Pharmaceuticals, Inc. (Ridgefield, CT)
Application Number:	06/796,467
Patent Claim Types: see list of patent claims	Process; Formulation; Composition; Dosage form; Use;

Drugs Protected by US Patent 4,933,360

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