Details for Patent: 5,135,950

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Summary for Patent: 5,135,950

Title:	Stable polymorphic form of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation
Abstract:	Stable and crystallographically essentially pure polymorphic form A of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)acrylamide may be prepared by crystallizing crude synthesis product from lower aliphatic carboxylic acid such as formic or acetic acid with a catalytic amount of hydrochloric or hydrobromic acid added. The product is a potent inhibitor of catechol-O-methyl-transferase enzyme (COMT).
Inventor(s):	Pippuri; Aino K. (Espoo, FI), Honkanen; Erkki J. (Vantaa, FI), Haarala; Jorma V. (Helsinki, FI)
Assignee:	Orion-yhtyma Oy (Espoo, FI)
Application Number:	07/606,717
Patent Claim Types: see list of patent claims	Compound; Process; Use; Composition;

Drugs Protected by US Patent 5,135,950

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Foreign Priority and PCT Information for Patent: 5,135,950

Foriegn Application Priority Data
Foreign Country	Foreign Patent Number	Foreign Patent Date
United Kingdom	8924838.9	Nov 03, 1989

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