Details for Patent: 5,310,912
✉ Email this page to a colleague
Summary for Patent: 5,310,912
Title: | Iodinated neuroprobe for mapping monoamine reuptake sites |
Abstract: | An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: ##STR1## wherein R=a C.sub.n H.sub.2n+1 group where n=0-6, an alkenyl group, a monofluoroalkyl group including .sup.n F where n=18 or 19, or a .sup.m C.sub.n H.sub.2n+1 group where n=1-6 and where m=11 or 14 for at least one .sup.m C; R'=a C.sub.n H.sub.2n+1 group where n=0-6, a p-iodophenylmethyl group, a p-iodophenylethyl group, a phenylmethyl group, or a phenylethyl group; X=an isotope of F, an isotope of Cl, an isotope of Br, an isotope of I, CH.sub.3, or Sn(R".sub.1 R".sub.2 R".sub.3); R".sub.1 =a C.sub.n H.sub.2n+1 group where n=1-6, or an aryl group; R".sub.2 =a C.sub.n H.sub.2n+1 group where n=1-6, or an aryl group; R".sub.3 =a C.sub.n H.sub.2n+1 group where n=1-6, or an aryl group; and Y=H only if X is an isotope of I, or R' is a p-iodophenylmethyl group, or R' is a p-iodophenylethyl group, else Y=an isotope of I. Related analogs are also provided. Additionally, a precursor of a radiolabled neuroprobe and a kit for preparing the iodinated neuroprobe are provided. |
Inventor(s): | Neumeyer; John L. (Wayland, MA), Milius; Richard A. (Boston, MA), Innis; Robert B. (Hamden, CT) |
Assignee: | Research Biochemicals Limited Partnership (Natick, MA) |
Application Number: | 07/841,617 |
Patent Claim Types: see list of patent claims | Compound; |
Drugs Protected by US Patent 5,310,912
Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
>Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
International Family Members for US Patent 5,310,912
Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
---|---|---|---|---|---|
European Patent Office | 0703791 | ⤷ Sign Up | 300123 | Netherlands | ⤷ Sign Up |
European Patent Office | 0703791 | ⤷ Sign Up | SPC/GB03/010 | United Kingdom | ⤷ Sign Up |
European Patent Office | 0703791 | ⤷ Sign Up | CA 2003 00010 | Denmark | ⤷ Sign Up |
European Patent Office | 0703791 | ⤷ Sign Up | C300123 | Netherlands | ⤷ Sign Up |
European Patent Office | 0703791 | ⤷ Sign Up | 03C0021 | France | ⤷ Sign Up |
European Patent Office | 0703791 | ⤷ Sign Up | 9/2003 | Austria | ⤷ Sign Up |
Austria | 228858 | ⤷ Sign Up | |||
>Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |