Details for Patent: 5,310,912

Summary for Patent: 5,310,912

Title:	Iodinated neuroprobe for mapping monoamine reuptake sites
Abstract:	An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: ##STR1## wherein R=a C.sub.n H.sub.2n+1 group where n=0-6, an alkenyl group, a monofluoroalkyl group including .sup.n F where n=18 or 19, or a .sup.m C.sub.n H.sub.2n+1 group where n=1-6 and where m=11 or 14 for at least one .sup.m C; R'=a C.sub.n H.sub.2n+1 group where n=0-6, a p-iodophenylmethyl group, a p-iodophenylethyl group, a phenylmethyl group, or a phenylethyl group; X=an isotope of F, an isotope of Cl, an isotope of Br, an isotope of I, CH.sub.3, or Sn(R".sub.1 R".sub.2 R".sub.3); R".sub.1 =a C.sub.n H.sub.2n+1 group where n=1-6, or an aryl group; R".sub.2 =a C.sub.n H.sub.2n+1 group where n=1-6, or an aryl group; R".sub.3 =a C.sub.n H.sub.2n+1 group where n=1-6, or an aryl group; and Y=H only if X is an isotope of I, or R' is a p-iodophenylmethyl group, or R' is a p-iodophenylethyl group, else Y=an isotope of I. Related analogs are also provided. Additionally, a precursor of a radiolabled neuroprobe and a kit for preparing the iodinated neuroprobe are provided.
Inventor(s):	Neumeyer; John L. (Wayland, MA), Milius; Richard A. (Boston, MA), Innis; Robert B. (Hamden, CT)
Assignee:	Research Biochemicals Limited Partnership (Natick, MA)
Application Number:	07/841,617
Patent Claim Types: see list of patent claims	Compound;

United States Patent 5,310,912: A Detailed Analysis of Scope, Claims, and Patent Landscape

Introduction

United States Patent 5,310,912, titled "Iodinated neuroprobe for mapping monoamine reuptake sites," is a significant patent in the field of neurochemistry and medical diagnostics. This patent, granted to the inventors, describes a novel iodinated neuroprobe used for mapping monoamine reuptake sites, particularly dopamine reuptake sites and cocaine binding sites. Here, we will delve into the scope, claims, and the broader patent landscape surrounding this invention.

Background and Invention Overview

The patent describes an iodinated neuroprobe, a compound designed to bind to monoamine reuptake sites in the brain. This neuroprobe is particularly useful for in vivo and in vitro experiments to study dopamine reuptake sites and cocaine binding sites. The invention includes both radiostable and radioactive variants of the iodinated neuroprobe, making it versatile for various research and diagnostic applications[4].

Scope of the Patent

The scope of the patent encompasses several key aspects:

Chemical Structure

The patent details the chemical structure of the iodinated neuroprobe, including its formula and synthesis route. The compound is described as having a specific molecular structure that allows it to bind effectively to monoamine reuptake sites[4].

Applications

The neuroprobe is useful for various applications, including:

• Research: For studying dopamine reuptake sites and cocaine binding sites in both human and non-human subjects.
• Diagnostic Imaging: The radioactive variants can be used in autoradiography, PET imaging, and other diagnostic techniques.
• Therapeutic Use: The radiostable version can be used as a drug to influence dopamine reuptake[4].

Experimental Use

The patent includes data from experiments conducted on baboons, showing the regional activity and brain uptake of the compound. This demonstrates the efficacy and specificity of the neuroprobe in targeting monoamine reuptake sites[4].

Claims of the Patent

The patent includes several claims that define the scope of the invention:

Independent Claims

• Claim 1 describes the iodinated neuroprobe compound and its formula.
• Claim 2 outlines the method of preparing the associated iodinated neuroprobe.
• Claim 3 details the kit for preparing the neuroprobe[4].

Dependent Claims

These claims further specify the uses and variations of the neuroprobe, including its application in autoradiography, PET imaging, and therapeutic use.

Patent Landscape

Prior Art

The patent references prior art compounds and methods but distinguishes itself through the specific structure and application of the iodinated neuroprobe. The prior art compounds are compared to the invention in figures included in the patent[4].

Classification

The patent is classified under several categories, including:

• C07D451/02: Heterocyclic compounds containing specific ring systems.
• A61K51/00: Medicinal preparations containing organic active ingredients[4].

International Context

While this patent is specific to the United States, similar inventions and research are likely to be found in international patent databases. For instance, the European Patent Office (EPO) and the World Intellectual Property Organization (WIPO) provide access to international patent applications and granted patents that may relate to similar neuroprobes[1].

Search and Analysis Tools

To conduct a thorough analysis of the patent landscape surrounding US 5,310,912, several tools and resources can be utilized:

USPTO Resources

• Patent Public Search: This tool allows for a comprehensive search of prior art and related patents.
• Global Dossier: Provides access to file histories and related applications from participating IP offices.
• Common Citation Document (CCD): Consolidates citation data from multiple offices, helping to identify relevant prior art[1].

International Databases

• European Patent Office (EPO): esp@cenet provides access to European patent databases.
• World Intellectual Property Organization (WIPO): PATENTSCOPE offers full-text search of international patent applications[1].

Economic and Research Implications

The Patent Claims Research Dataset by the USPTO can provide insights into the economic and research trends related to this patent. This dataset includes detailed information on claims from US patents and applications, which can help in understanding the scope and impact of the patent[3].

Legal Status

The patent has expired, as indicated by its legal status. This means that the invention is now in the public domain, and the specific claims and methods described can be freely used without infringing on the original patent[4].

Key Takeaways

• Invention Scope: The patent covers a specific iodinated neuroprobe for mapping monoamine reuptake sites.
• Claims: The patent includes claims for the compound, its preparation, and its use in various applications.
• Patent Landscape: The invention is classified under specific categories and can be analyzed using various USPTO and international tools.
• Legal Status: The patent has expired, making the invention publicly available.

FAQs

Q: What is the primary use of the iodinated neuroprobe described in US 5,310,912?

A: The primary use is for mapping monoamine reuptake sites, particularly dopamine reuptake sites and cocaine binding sites.

Q: Can the neuroprobe be used in therapeutic applications?

A: Yes, the radiostable version of the neuroprobe can be used as a drug to influence dopamine reuptake.

Q: How can one search for related patents and prior art?

A: Tools like the USPTO's Patent Public Search, Global Dossier, and international databases such as EPO's esp@cenet and WIPO's PATENTSCOPE can be used.

Q: What is the current legal status of US 5,310,912?

A: The patent has expired, making the invention publicly available.

Q: Are there any international equivalents of this patent?

A: While the patent is specific to the US, similar inventions may be found in international patent databases, which can be searched using resources like EPO and WIPO.

Sources

1. USPTO - Search for patents: https://www.uspto.gov/patents/search
2. Regulations.gov - Patent Term Extension Application for DaTscan: https://www.regulations.gov/docket/FDA-2011-E-0367
3. USPTO - Patent Claims Research Dataset: https://www.uspto.gov/ip-policy/economic-research/research-datasets/patent-claims-research-dataset
4. Google Patents - Iodinated neuroprobe for mapping monoamine reuptake sites: https://patents.google.com/patent/US5310912A/en

Drugs Protected by US Patent 5,310,912

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

International Family Members for US Patent 5,310,912

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
European Patent Office	0703791		300123	Netherlands
European Patent Office	0703791		SPC/GB03/010	United Kingdom
European Patent Office	0703791		CA 2003 00010	Denmark