Details for Patent: 5,431,900

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Summary for Patent: 5,431,900

Title:	Ester-substituted diaminedithiols and radiolabeled complexes thereof
Abstract:	Radiopharmaceuticals consisting essentially of a lipophilic, charge neutral radionuclide complex of a diaminedithiol ligand having 1-4 ester groups of the formula --A--COOR where A is a straight or branched chain alkylene of 0-10 carbon atoms and R is an alkyl group of 1-10 carbon atoms are useful in radioimaging brain perfusion in primates. Ester-substituted diaminedithiols in sterile, pharmaceutically acceptable form, and kits of the diaminedithiols and sterile, non-pyrogenic reducing agents for reducing preselected radionuclides are also provided. Technetium-99m is a preferred radionuclide.
Inventor(s):	Bergstein; Paul L. (Norwood, MA), Cheesman; Edward H. (Townsend, MA), Watson; Alan D. (Andover, MA)
Assignee:	The Du Pont Merck Pharmaceutical Company (Wilmington, DE)
Application Number:	08/139,894
Patent Claim Types: see list of patent claims	Compound; Device;

Drugs Protected by US Patent 5,431,900

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