Details for Patent: 5,859,006
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Summary for Patent: 5,859,006
| Title: | Tetracyclic derivatives; process of preparation and use |
| Abstract: | A compound of formula (I) ##STR1## and salts and solvates thereof, in which: R.sup.0 represents hydrogen, halogen or C.sub.1-6 alkyl; R.sup.1 represents hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, haloC.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkylC.sub.1-3 alkyl, arylC.sub.1-3 alkyl or heteroarylC.sub.1-3 alkyl; R.sup.2 represents an optionally substituted monocyclic aromatic ring selected from benzene, thiophene, furan and pyridine or an optionally substituted bicyclic ring ##STR2## attached to the rest of the molecule via one of the benzene ring carbon atoms and wherein the fused ring A is a 5- or 6-membered ring which may be saturated or partially or fully unsaturated and comprises carbon atoms and optionally one or two heteroatoms selected from oxygen, sulphur and nitrogen; and R.sup.3 represents hydrogen or C.sub.1-3 alkyl, or R.sup.1 and R.sup.3 together represent a 3- or 4-membered alkyl or alkenyl chain. A compound of formula (I) is a potent and selective inhibitor of cyclic guanosine 3', 5'-monophosphate specific phosphodiesterase (cGMP specific PDE) having a utility in a variety of therapeutic areas where such inhibition is beneficial, including the treatment of cardiovascular disorders. |
| Inventor(s): | Daugan; Alain Claude-Marie (Les Ulis, FR) |
| Assignee: | ICOS Corporation (Bothell, WA) |
| Application Number: | 08/669,389 |
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Patent Claim Types: see list of patent claims | Compound; Use; Composition; Process; |
Drugs Protected by US Patent 5,859,006
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 5,859,006
| Foriegn Application Priority Data | ||
| Foreign Country | Foreign Patent Number | Foreign Patent Date |
| United Kingdom | 9401090 | Jan 21, 1994 |
| PCT Information | |||
| PCT Filed | January 19, 1995 | PCT Application Number: | PCT/EP95/00183 |
| PCT Publication Date: | July 27, 1995 | PCT Publication Number: | WO95/19978 |
International Family Members for US Patent 5,859,006
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| European Patent Office | 0740668 | ⤷ Sign Up | SPC004/2003 | Ireland | ⤷ Sign Up |
| European Patent Office | 0740668 | ⤷ Sign Up | 91017 | Luxembourg | ⤷ Sign Up |
| European Patent Office | 0740668 | ⤷ Sign Up | PA2003001 | Lithuania | ⤷ Sign Up |
| European Patent Office | 0740668 | ⤷ Sign Up | 300124 | Netherlands | ⤷ Sign Up |
| European Patent Office | 0740668 | ⤷ Sign Up | SPC/GB03/007 | United Kingdom | ⤷ Sign Up |
| European Patent Office | 0740668 | ⤷ Sign Up | PA2003001,C0740668 | Lithuania | ⤷ Sign Up |
| European Patent Office | 0740668 | ⤷ Sign Up | CA 2003 00008 | Denmark | ⤷ Sign Up |
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
