Details for Patent: 5,968,895
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Summary for Patent: 5,968,895
Title: | Pharmaceutical formulations for sustained drug delivery |
Abstract: | Sustained delivery formulations comprising a water-insoluble complex of a peptide and a carrier macromolecule are disclosed. The formulations of the invention allow for loading of high concentrations of peptide in a small volume and for delivery of a pharmaceutically active peptide for prolonged periods, e.g., one month, after administration of the complex. The complexes of the invention can be milled or crushed to a fine powder. In powdered form, the complexes form stable aqueous suspensions and dispersions, suitable for injection. In a preferred embodiment, the peptide of the complex is an LHRH analogue, preferably an LHRH antagonist, and the carrier macromolecule is an anionic polymer, preferably carboxymethylcellulose. Methods of making the complexes of the invention, and methods of using LHRH-analogue-containing complexes to treat conditions treatable with an LHRH analogue, are also disclosed. |
Inventor(s): | Gefter; Malcolm L. (Lincoln, MA), Barker; Nicholas (Southborough, MA), Musso; Gary (Hopkinton, MA), Molineaux; Christopher J. (Brookline, MA) |
Assignee: | Praecis Pharmaceuticals, Inc. (Cambridge, MA) |
Application Number: | 08/762,747 |
Patent Claim Types: see list of patent claims | Composition; Dosage form; Delivery; |
Drugs Protected by US Patent 5,968,895
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International Family Members for US Patent 5,968,895
Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
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Argentina | 010351 | ⤷ Try a Trial | |||
Austria | 378059 | ⤷ Try a Trial | |||
Austria | 383165 | ⤷ Try a Trial | |||
>Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |