Details for Patent: 7,217,713
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Summary for Patent: 7,217,713
Title: | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase |
Abstract: | N-substituted 5-hydroxypyrimidin-6-one-4-carboxamides of formula: ##STR00001## are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined herein. These compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds-are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described. |
Inventor(s): | Crescenzi; Benedetta (Rome, IT), Gardelli; Cristina (Ariccia, IT), Muraglia; Ester (Rome, IT), Nizi; Emanuela (Siena, IT), Orvieto; Federica (Rome, IT), Pace; Paola (Rome, IT), Pescatore; Giovanna (Cosenza, IT), Petrocchi; Alessia (Rome, IT), Poma; Marco (Grosseto, IT), Rowley; Michael (Axa, IT), Scarpelli; Rita (Rome, IT), Summa; Vincenzo (Velletri, IT) |
Assignee: | Istituto Di Richerche Di Biologia Molecolare P. Angeletti S.p.A. (Pomezia (Rome), IT) |
Application Number: | 11/491,815 |
Patent Claim Types: see list of patent claims | Use; |
Drugs Protected by US Patent 7,217,713
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International Family Members for US Patent 7,217,713
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European Patent Office | 1441735 | ⤷ Sign Up | CA 2008 00021 | Denmark | ⤷ Sign Up |
European Patent Office | 1441735 | ⤷ Sign Up | 91428 | Luxembourg | ⤷ Sign Up |
European Patent Office | 1441735 | ⤷ Sign Up | C20080001 00016 | Estonia | ⤷ Sign Up |
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