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Last Updated: December 22, 2024

Details for Patent: 7,270,800


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Which drugs does patent 7,270,800 protect, and when does it expire?

Patent 7,270,800 protects VIZAMYL and is included in one NDA.

This patent has fifty-nine patent family members in nineteen countries.

Summary for Patent: 7,270,800
Title:Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
Abstract: This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
Inventor(s): Klunk; William E. (Pittsburgh, PA), Mathis, Jr.; Chester A. (Pittsburgh, PA), Wang; Yanming (Imperial, PA)
Assignee: University of Pittsburgh (Pittsburgh, PA)
Application Number:10/388,173
Patent Claim Types:
see list of patent claims
Compound; Use; Composition; Formulation;
Patent landscape, scope, and claims:

United States Patent 7,270,800: A Detailed Analysis of Scope, Claims, and Patent Landscape

Introduction

The United States Patent 7,270,800, titled "Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition," is a significant patent in the field of biomedical research. This patent, granted to researchers, outlines novel thioflavin derivatives and their applications in diagnosing and treating Alzheimer's disease. Here, we will delve into the scope, claims, and the broader patent landscape surrounding this invention.

Background of the Patent

Invention Overview

The patent describes thioflavin derivatives designed for antemortem diagnosis of Alzheimer's disease, as well as their use in in vivo imaging and the prevention of amyloid deposition. These derivatives are crucial for early detection and potential therapeutic interventions in Alzheimer's disease[4].

Public Funding

It is important to note that many biomedical patents, including those related to Alzheimer's research, often receive public funding. For instance, the National Institutes of Health (NIH) frequently supports such research through grants. However, the specific patent in question does not explicitly mention public funding in its disclosure[1].

Scope of the Patent

Claim Construction

The scope of a patent is largely defined by its claims. For US Patent 7,270,800, the claims are detailed and specific, outlining the chemical structures of the thioflavin derivatives, their methods of use, and the applications in medical diagnostics and therapy.

  • Independent Claims: These claims define the core invention and are critical in determining the patent's scope. For example, Claim 1 might describe a specific thioflavin derivative, its chemical structure, and its use in diagnosing Alzheimer's disease.
  • Dependent Claims: These claims build upon the independent claims and provide additional details or variations of the invention. They might include specific methods of synthesis, dosages, or additional applications[5].

Patent Scope Metrics

The scope of a patent can also be measured using metrics such as independent claim length and independent claim count. These metrics can indicate the breadth and complexity of the patent. For instance, longer independent claims or a higher number of claims can suggest a broader scope, although this does not always correlate with patent quality[3].

Claims Analysis

Claim Language

The claims in US Patent 7,270,800 are written to be as specific as possible while covering the full range of the invention. Here is an example of how claim language might be structured:

  • Claim 1: "A thioflavin derivative of the formula [specific chemical structure], wherein the derivative is used for in vivo imaging of amyloid deposits in a patient."
  • Claim 2: "The thioflavin derivative of Claim 1, wherein the derivative is administered intravenously."

The clarity and specificity of these claims are crucial for defining the patent's boundaries and ensuring that they are enforceable[5].

Claim Dependency

Claims in a patent can be either independent or dependent. Independent claims stand alone and define the invention, while dependent claims refer back to and further limit the independent claims. For example:

  • Claim 3: "The method of Claim 2, wherein the thioflavin derivative is used in combination with another diagnostic agent."

Understanding the dependency between claims helps in interpreting the full scope of the patent[3].

Patent Landscape

Related Patents

The patent landscape for thioflavin derivatives and Alzheimer's disease diagnostics is complex and includes numerous other patents. These patents may cover different aspects such as other diagnostic methods, therapeutic agents, or imaging technologies.

  • Prior Art: The prior art section of the patent lists earlier patents and publications that are relevant to the invention. This helps in understanding how the current patent differs from existing knowledge in the field[4].

Competitors and Collaborators

Companies and research institutions involved in Alzheimer's disease research often hold multiple patents related to diagnostics and therapeutics. Understanding the patent portfolios of competitors and potential collaborators is essential for navigating the intellectual property landscape.

  • Public-Private Partnerships: Many biomedical patents, especially those related to significant diseases like Alzheimer's, result from public-private partnerships. These partnerships can involve government funding, academic research, and industry collaboration[1].

Regulatory and Legal Aspects

Patent Claim Construction

The construction of patent claims is a critical legal aspect that determines the scope of protection. The Federal Circuit has established various precedents on claim construction, which are essential for interpreting the claims of US Patent 7,270,800. For instance, the Supreme Court's decision in Nautilus, Inc. v. Biosig Instruments, Inc. emphasizes the importance of clear and definite claim language[5].

Litigation and Licensing

Patents in the biomedical field are often subject to litigation and licensing agreements. The clarity and validity of the claims in US Patent 7,270,800 would be crucial in any legal disputes or licensing negotiations.

Economic Impact

Innovation Incentives

Patents like US 7,270,800 play a significant role in incentivizing innovation by providing exclusive rights to the inventors. This exclusivity allows them to recoup their investment in research and development.

  • Public Funding Impact: Public funding can significantly impact the economic landscape by supporting research that might not be viable under private funding alone. This can lead to more innovative solutions being developed and patented[1].

Market Dominance

The patent's scope and claims can influence market dominance in the field of Alzheimer's disease diagnostics and therapeutics. Companies holding broad and valid patents can have a competitive advantage, influencing market dynamics and pricing.

Future Directions

Continuing Research

The field of Alzheimer's disease research is continuously evolving, with new discoveries and innovations emerging regularly. Future patents may build upon the thioflavin derivatives described in US Patent 7,270,800 or introduce entirely new approaches.

  • Patent Continuations: The use of patent continuations can allow inventors to expand their patent coverage as new developments occur. This is particularly relevant in rapidly advancing fields like biomedical research[1].

Key Takeaways

  • Specific Claims: The patent's claims are detailed and specific, defining the scope of the invention clearly.
  • Public-Private Partnerships: Many biomedical patents, including those related to Alzheimer's research, involve public-private partnerships.
  • Regulatory and Legal Aspects: Clear and definite claim language is crucial for legal interpretations and disputes.
  • Economic Impact: Patents incentivize innovation and can influence market dynamics.
  • Future Directions: Continuing research and patent continuations are essential for maintaining a competitive edge in biomedical innovation.

FAQs

What is the main invention described in US Patent 7,270,800?

The main invention described in US Patent 7,270,800 is novel thioflavin derivatives used for antemortem diagnosis of Alzheimer's disease, in vivo imaging, and the prevention of amyloid deposition.

How are the claims in this patent constructed?

The claims are constructed to be specific and detailed, with independent claims defining the core invention and dependent claims providing additional details or variations.

What role does public funding play in biomedical patents like US 7,270,800?

Public funding, often from institutions like the NIH, can support the research leading to such patents, although the specific patent in question does not explicitly mention public funding.

How does the patent landscape affect the scope of US Patent 7,270,800?

The patent landscape includes numerous related patents, and understanding this landscape is crucial for navigating intellectual property rights and potential collaborations or disputes.

What are the economic implications of holding a patent like US 7,270,800?

Holding such a patent can provide exclusive rights, incentivize innovation, and influence market dynamics, giving the holder a competitive advantage in the field of Alzheimer's disease diagnostics and therapeutics.

Sources

  1. Public and private investments in biomedical research - AEA Web
  2. Patent Claims Research Dataset - USPTO
  3. Patent Claims and Patent Scope - Hoover Institution
  4. Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease - Google Patents
  5. Patent Claim Construction in the Federal Circuit - Thomson Reuters

More… ↓

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Drugs Protected by US Patent 7,270,800

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Ge Healthcare VIZAMYL flutemetamol f-18 INJECTABLE;INTRAVENOUS 203137-001 Oct 25, 2013 DISCN Yes No ⤷  Subscribe ⤷  Subscribe Y Y DIAGNOSTIC RADIOIMAGING ⤷  Subscribe
Ge Healthcare VIZAMYL flutemetamol f-18 INJECTABLE;INTRAVENOUS 203137-002 Oct 25, 2013 RX Yes Yes ⤷  Subscribe ⤷  Subscribe Y Y DIAGNOSTIC RADIOIMAGING ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 7,270,800

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 1611115 ⤷  Subscribe CA 2015 00009 Denmark ⤷  Subscribe
European Patent Office 1611115 ⤷  Subscribe C300724 Netherlands ⤷  Subscribe
European Patent Office 1611115 ⤷  Subscribe 15C0005 France ⤷  Subscribe
European Patent Office 1611115 ⤷  Subscribe C20150004 00139 Estonia ⤷  Subscribe
European Patent Office 1334091 ⤷  Subscribe PA2015001 Lithuania ⤷  Subscribe
European Patent Office 1611115 ⤷  Subscribe 92634 Luxembourg ⤷  Subscribe
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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