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Last Updated: December 23, 2024

Details for Patent: 7,538,133


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Summary for Patent: 7,538,133
Patent landscape, scope, and claims:
Title:Benzimidazole derivatives, their production and use
Abstract: Benzimidazole derivatives of the formula (I): ##STR00001## wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R' group; R.sup.1 is hydrogen or an optionally substituted hydrocarbon residue; R.sup.2 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; R' is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or convertible to an anion; Y is --O--, --S(O).sub.m-- or --N(R.sup.4)-- wherein m is an integer of 0, 1 or 2 and R.sup.4 is hydrogen or an optionally substituted alkyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.
Inventor(s): Naka; Takehiko (Higashinada-ku, JP), Nishikawa; Kohei (Nishikyo-ku, JP), Kato; Takeshi (Higashiosaka, JP)
Assignee: Takeda Pharmaceutical Company Limited (Osaka, JP)
Application Number:11/594,982
Patent Claim Types:
see list of patent claims
Compound;

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Drugs Protected by US Patent 7,538,133

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 7,538,133

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan1990-113148Apr 27, 1990
Japan1990-141942May 30, 1990
Japan1990-208662Aug 06, 1990
Japan1990-264579Oct 01, 1990
Japan1990-413679Dec 24, 1990

International Family Members for US Patent 7,538,133

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 0459136 ⤷  Subscribe SPC/GB97/018 United Kingdom ⤷  Subscribe
European Patent Office 0459136 ⤷  Subscribe C970044 Netherlands ⤷  Subscribe
European Patent Office 0459136 ⤷  Subscribe 98C0016 Belgium ⤷  Subscribe
European Patent Office 0459136 ⤷  Subscribe 8/1998 Austria ⤷  Subscribe
European Patent Office 0459136 ⤷  Subscribe SZ 8/1998 Austria ⤷  Subscribe
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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