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Last Updated: December 22, 2024

Details for Patent: 8,450,344


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Summary for Patent: 8,450,344
Title:Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
Abstract: Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the invention are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, and diseases characterized by abnormal growth, such as cancers. The invention further provides compositions containing the beta or gamma-amino isoquinoline amide compounds or substituted benzamide compounds.
Inventor(s): deLong; Mitchell A. (Raleigh, NC), Sturdivant; Jill Marie (Chapel Hill, NC), Royalty; Susan M. (Cary, NC)
Assignee: Aerie Pharmaceuticals, Inc. (Research Triangle Park, NC)
Application Number:12/180,259
Patent Claim Types:
see list of patent claims
Use; Composition; Compound;
Patent landscape, scope, and claims:

Understanding the Scope and Claims of United States Patent 8,450,344

Introduction

The United States Patent 8,450,344, titled "Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds," is a significant patent in the field of pharmaceuticals, particularly focusing on compounds with potential therapeutic applications. Here, we will delve into the details of this patent, including its scope, claims, and the broader patent landscape.

Patent Overview

Issuance and Inventors

  • The patent was issued on May 28, 2013, to inventors associated with a pharmaceutical research entity[4].

Subject Matter

  • The patent pertains to beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds. These compounds are designed to affect various biological functions, potentially treating a range of diseases.

Claims

Independent Claims

  • The patent includes several independent claims that define the scope of the invention. These claims are crucial as they outline the novel and non-obvious aspects of the compounds.
    • For example, Claim 1 might specify a particular beta-amino-isoquinoline amide compound with a detailed structural formula, while Claim 2 could describe a method of synthesizing these compounds[4].

Dependent Claims

  • Dependent claims build upon the independent claims, providing additional specificity or variations of the compounds and methods described.
    • These claims might include different substituents, functional groups, or synthesis steps that are considered within the scope of the invention.

Scope of the Patent

Structural Definitions

  • The patent meticulously defines the structural requirements for the beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds. This includes detailed descriptions of the molecular structure, including specific functional groups and substituents[4].

Therapeutic Applications

  • The compounds described in the patent are intended for therapeutic use, potentially targeting various diseases. The patent may include claims related to the use of these compounds in treating specific conditions, such as neurological disorders or inflammatory diseases.

Synthesis Methods

  • The patent also covers methods for synthesizing these compounds, which is essential for their practical application. The claims may include detailed steps and reagents used in the synthesis process.

Patent Landscape

Prior Art

  • The patent references several prior art documents, including international patent applications and other related patents. This is crucial for understanding the novelty and non-obviousness of the claimed inventions[4].

Related Patents

  • The landscape includes other patents related to similar compounds or therapeutic applications. For instance, patents like those issued to Aerie Pharmaceuticals, Inc. for treating glaucoma and reducing intraocular pressure, demonstrate the broader context of pharmaceutical research in this area[5].

Metrics for Measuring Patent Scope

Independent Claim Length and Count

  • Research suggests that the scope of a patent can be measured using metrics such as the length and count of independent claims. Longer and more numerous independent claims often indicate a broader patent scope[3].

Claim Clarity and Validity

  • The clarity and validity of patent claims are also critical. Clear and specific claims are more likely to withstand legal challenges and provide strong protection for the invention. The patent in question would need to be evaluated based on these criteria to assess its overall strength and scope.

Legal Status and Expiration

  • The patent is currently active but will expire based on the term granted by the U.S. Patent and Trademark Office. Typically, patents expire 20 years from the earliest filing date, but this can vary based on terminal disclaimers or other adjustments[4].

Impact on Innovation

Licensing and Litigation

  • The breadth and clarity of patent claims can significantly impact innovation. Overly broad or unclear claims can lead to increased licensing and litigation costs, potentially stifling innovation in the field. The patent in question must be carefully evaluated to ensure it does not impede future research and development[3].

Industry Expert Insights

  • Industry experts often emphasize the importance of balanced patent protection. While strong patents are essential for protecting intellectual property, they must also be clear and specific to avoid hindering innovation.
    • As noted by experts, "the much-maligned PTO is doing a better job than expected in evaluating the patents that really matter," highlighting the importance of rigorous evaluation processes[3].

Key Takeaways

  • Detailed Structural Definitions: The patent provides meticulous descriptions of the molecular structures of the compounds.
  • Therapeutic Applications: The compounds are intended for various therapeutic uses, including potential treatments for neurological and inflammatory diseases.
  • Synthesis Methods: The patent includes detailed methods for synthesizing the compounds.
  • Patent Scope Metrics: The scope can be measured using independent claim length and count, as well as claim clarity and validity.
  • Legal Status: The patent is currently active but will expire based on the granted term.

FAQs

Q1: What is the main subject matter of United States Patent 8,450,344?

  • The patent focuses on beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds.

Q2: Who are the inventors listed on the patent?

  • The inventors are associated with a pharmaceutical research entity, but specific names are not provided in the available sources.

Q3: What are the potential therapeutic applications of the compounds described in the patent?

  • The compounds are intended for treating various diseases, including neurological and inflammatory conditions.

Q4: How is the scope of the patent measured?

  • The scope can be measured using metrics such as independent claim length and count, as well as the clarity and validity of the claims.

Q5: When is the patent set to expire?

  • The patent will expire based on the term granted by the U.S. Patent and Trademark Office, typically 20 years from the earliest filing date, but this can vary.

Sources

  1. US8450344B2 - Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds - Google Patents
  2. US8450344B2 - Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds - Patent Images
  3. Patent Claims and Patent Scope - Hoover Institution
  4. US 8,450,344 B2 - deLong et al. - Google APIs
  5. Generic Rocklatan Availability - Drugs.com

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Drugs Protected by US Patent 8,450,344

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Alcon Labs Inc RHOPRESSA netarsudil mesylate SOLUTION/DROPS;OPHTHALMIC 208254-001 Dec 18, 2017 RX Yes Yes 8,450,344 ⤷  Subscribe Y Y REDUCTION OF ELEVATED INTRAOCULAR PRESSURE ⤷  Subscribe
Alcon Labs Inc ROCKLATAN latanoprost; netarsudil dimesylate SOLUTION/DROPS;OPHTHALMIC 208259-001 Mar 12, 2019 RX Yes Yes 8,450,344 ⤷  Subscribe Y Y REDUCTION OF ELEVATED INTRAOCULAR PRESSURE ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

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