Details for Patent: 8,591,864
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Summary for Patent: 8,591,864
| Title: | Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents |
| Abstract: | Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The pharmacological compositions employ a polysaccharide iron oxide complex, wherein the polysaccharide is a modified polyol such as a carboxyalkylated reduced dextran. The complex is stable to terminal sterilization by autoclaving. The compositions are suitable for parenteral administration to a subject for the treatment of iron deficiencies or as MRI contrast agent. The complex is substantially immunosilent, provide minimal anaphylaxis and undergo minimal dissolution in vivo. The pharmacological compositions of the complex contain minimal free iron which can be quantified by a variety of methods. |
| Inventor(s): | MAUSUSGroman; Ernest V. (Brookline, MA), Paul; Kenneth G. (Holliston, MA), Frigo; Timothy B. (Waltham, MA), Bengele; Howard (Canton, MA), Lewis; Jerome M. (Newton, MA) |
| Assignee: | AMAG Pharmaceuticals, Inc. (Lexington, MA) |
| Application Number: | 13/734,339 |
| Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for patent 8,591,864 |
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Patent Claim Types: see list of patent claims | Compound; Composition; |
Drugs Protected by US Patent 8,591,864
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International Family Members for US Patent 8,591,864
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| European Patent Office | 1169062 | ⤷ Sign Up | C300558 | Netherlands | ⤷ Sign Up |
| European Patent Office | 1169062 | ⤷ Sign Up | CA 2012 00050 | Denmark | ⤷ Sign Up |
| European Patent Office | 1169062 | ⤷ Sign Up | 92114 | Luxembourg | ⤷ Sign Up |
| European Patent Office | 1169062 | ⤷ Sign Up | C01169062/01 | Switzerland | ⤷ Sign Up |
| European Patent Office | 1169062 | ⤷ Sign Up | 1290043-7 | Sweden | ⤷ Sign Up |
| European Patent Office | 1169062 | ⤷ Sign Up | 300558 | Netherlands | ⤷ Sign Up |
| European Patent Office | 1169062 | ⤷ Sign Up | 2012C/052 | Belgium | ⤷ Sign Up |
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
