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Last Updated: December 22, 2024

Details for Patent: 8,828,356


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Which drugs does patent 8,828,356 protect, and when does it expire?

Patent 8,828,356 protects ZOKINVY and is included in one NDA.

This patent has nine patent family members in six countries.

Summary for Patent: 8,828,356
Title:Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis
Abstract: Although it can be farnesylated, the mutant lamin A protein expressed in Hutchinson Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting defarnesylation. The result is an aberrant farnesylated protein (called "progerin") that alters normal lamin A function as a dominant negative, as well as assuming its own aberrant function through its association with the nuclear membrane. The retention of farnesylation, and potentially other abnormal properties of progerin and other abnormal lamin gene protein products, produces disease. Farnesyltransferase inhibitors (FTIs) (both direct effectors and indirect inhibitors) will inhibit the formation of progerin, cause a decrease in lamin A protein, and/or an increase prelamin A protein. Decreasing the amount of aberrant protein improves cellular effects caused by and progerin expression. Similarly, treatment with FTIs should improve disease status in progeria and other laminopathies. In addition, elements of atherosclerosis and aging in non-laminopathy individuals will improve after treatment with farnesyltransferase inhibitors.
Inventor(s): Gordon; Leslie B. (Foxboro, MA), Collins; Francis S. (Rockville, MD), Glover; Thomas (Ypsilanti, MI), Glynn; Michael W. (Darien, CT), Capell; Brian C. (Philadelphia, PA), Cox; Adrienne D. (Chapel Hill, NC), Der; Channing J. (Chapel Hill, NC)
Assignee: Progeria Research Foundation, Inc. (Peabody, MA) The United States of America as represented by the Secretary of the Department of Health and Human Services (Washington, DC) N/A (Chapel Hill, NC) The University of North Carolina at Chapel Hill (Ann Arbor, MI) The Regents of the University of Michigan (N/A)
Application Number:13/857,052
Patent Claim Types:
see list of patent claims
Use;
Patent landscape, scope, and claims:

Analyzing the Scope and Claims of United States Patent 8,828,356: A Comprehensive Guide

Introduction to Patent Analysis

When analyzing a patent, it is crucial to understand the scope, claims, and the broader patent landscape. This analysis helps in assessing the patent's validity, identifying potential competitors, and making informed business decisions.

Understanding the Patent in Question

United States Patent 8,828,356 is a specific patent that requires a detailed examination of its claims, descriptions, and the context within which it was granted.

Patent Details

  • Patent Number: 8,828,356
  • Title: [Insert the title of the patent here, as this information is not provided in the sources]
  • Inventors: [Insert the inventors' names here]
  • Assignee: [Insert the assignee's name here]
  • Filing Date: [Insert the filing date here]
  • Grant Date: [Insert the grant date here]

Scope of the Patent

The scope of a patent is defined by its claims, which are the legally binding descriptions of the invention. Here’s how to analyze the scope:

Claims Analysis

  • Independent Claims: These are the broadest claims that define the invention. Analyze each independent claim to understand the core aspects of the invention.
  • Dependent Claims: These claims are narrower and build upon the independent claims. They often add specific details or limitations to the invention.
  • Claim Construction: Interpret the claims in light of the specification and any relevant prior art to understand their full scope.

Patent Landscape Analysis

Patent landscape analysis provides a broader view of the technological domain in which the patent resides.

Identifying Competitors

  • Use tools like the USPTO's Patent Public Search, Global Dossier, or international databases such as those from the European Patent Office (EPO) or the World Intellectual Property Organization (WIPO) to identify other patents in the same technological field[1][4].
  • Analyze the patent portfolios of competitors to understand their strengths and weaknesses.

Legal Status and Expiry Dates

  • Check the legal status of the patent (alive, pending, lapsed, revoked, or expired) to determine its current validity and potential expiry dates[3].
  • This information is crucial for planning licensing strategies or assessing the risk of infringement.

Market Developments

  • Look into market trends, mergers and acquisitions, licensing activities, and litigation related to the technology. This can be done through advanced patent landscape reports that include charts and analytics[3].

Tools and Resources for Patent Analysis

USPTO Resources

  • Patent Public Search: A powerful tool that replaced legacy search tools, providing enhanced access to prior art[1].
  • Global Dossier: Allows access to file histories of related applications from participating IP Offices, including the IP5 Offices[1].
  • Patent and Trademark Resource Centers (PTRCs): Local resources that offer training in patent search techniques and access to various search tools[1].

International Databases

  • European Patent Office (EPO): Provides access to Europe's patent databases through esp@cenet and machine translations for some languages[1].
  • World Intellectual Property Organization (WIPO): Offers the PATENTSCOPE ® Search Service, which includes full-text searches of international patent applications and machine translations[1].

Advanced Patent Landscape Analysis

  • Utilize computer tools and human intelligence to analyze and organize vast amounts of patent data. This can include 3D maps, MS Excel reports, and integration of multiple studies[3].

Steps to Conduct a Preliminary Patent Search

Step-by-Step Strategy

  • Start with a broad search using keywords and classifications (e.g., Cooperative Patent Classification - CPC)[4].
  • Use the USPTO's web-based tutorial to guide your search strategy[1].

Using Classification Schemes

  • The CPC database can be searched to find relevant classification schemes, helping to narrow down the search to specific technological areas[4].

Full-Text Searching

  • Utilize databases that allow full-text searching of patent grants and applications from the United States and over 100 other patent offices worldwide[4].

Analyzing Prior Art

Prior art is any evidence that your invention is already known. Analyzing prior art is crucial to determine the novelty and non-obviousness of your invention.

Common Citation Document (CCD)

  • Use the CCD application to consolidate prior art cited by all participating offices for the family members of a patent application[1].

Sequence Listings

  • For patents involving sequences, use the Publication Site for Issued and Published Sequences (PSIPS) to view sequence listings and other mega items[1].

Legal and Business Implications

Licensing Strategies

  • Identify patents that are about to expire or have not been updated to develop new licensing strategies[3].

Risk Assessment

  • Analyze litigation, opposition activities, and other market developments to minimize business risks and capitalize on opportunities[3].

R&D Investments

  • Determine the nature of investments required for Research & Development (R&D) based on the patent landscape analysis[3].

Conclusion

Analyzing the scope and claims of United States Patent 8,828,356 involves a thorough examination of its legal descriptions, the broader technological landscape, and the use of various tools and resources. This analysis is essential for making informed decisions about licensing, R&D investments, and market strategies.

Key Takeaways

  • Claims Analysis: Understand the independent and dependent claims to define the scope of the patent.
  • Patent Landscape: Identify competitors, legal status, and market developments to assess the patent's position.
  • Tools and Resources: Utilize USPTO resources, international databases, and advanced patent landscape analysis tools.
  • Prior Art: Analyze prior art to determine the novelty and non-obviousness of the invention.
  • Business Implications: Develop licensing strategies, assess risks, and plan R&D investments based on the analysis.

FAQs

Q: What is the purpose of conducting a patent landscape analysis?

A: Patent landscape analysis helps in understanding the entire landscape of a technology domain, identifying competitors, and extracting valuable legal, business, and technical insights.

Q: How can I identify competitors in the same technological field?

A: Use tools like the USPTO's Patent Public Search, Global Dossier, or international databases such as those from the EPO or WIPO to identify other patents in the same field.

Q: What is the Common Citation Document (CCD) and how is it used?

A: The CCD consolidates prior art cited by all participating offices for the family members of a patent application, enabling the visualization of search results from several offices on a single page.

Q: How can I determine the legal status and expiry dates of a patent?

A: Check the legal status through databases like the USPTO's Patent Public Search or Global Dossier, and note the expected expiry dates to plan accordingly.

Q: What are the benefits of using advanced patent landscape analysis tools?

A: These tools provide detailed insights into patent trends, market developments, and business risks, helping organizations make informed decisions and capitalize on opportunities.

Sources

  1. USPTO - Search for patents: https://www.uspto.gov/patents/search
  2. USA.gov - U.S. Patent and Trademark Office (USPTO): https://www.usa.gov/agencies/u-s-patent-and-trademark-office
  3. Sagacious Research - Navigating Technological Domains with Patent Landscape Analysis: https://sagaciousresearch.com/blog/navigating-technological-domains-with-patent-landscape-analysis/
  4. Clemson University - Advanced Patent Searching: https://clemson.libguides.com/advanced_patent_searching

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Drugs Protected by US Patent 8,828,356

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Sentynl Theraps Inc ZOKINVY lonafarnib CAPSULE;ORAL 213969-001 Nov 20, 2020 RX Yes No ⤷  Subscribe ⤷  Subscribe REDUCING THE RISK OF MORTALITY IN HUTCHINSON-GILFORD PROGERIA SYNDROME (HGPS) ⤷  Subscribe
Sentynl Theraps Inc ZOKINVY lonafarnib CAPSULE;ORAL 213969-002 Nov 20, 2020 RX Yes Yes ⤷  Subscribe ⤷  Subscribe REDUCING THE RISK OF MORTALITY IN HUTCHINSON-GILFORD PROGERIA SYNDROME (HGPS) ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 8,828,356

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 547536 ⤷  Subscribe
Australia 2003301446 ⤷  Subscribe
Canada 2501464 ⤷  Subscribe
European Patent Office 1552020 ⤷  Subscribe
European Patent Office 1853265 ⤷  Subscribe
Japan 2006507845 ⤷  Subscribe
Japan 4436800 ⤷  Subscribe
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.