Details for Patent: RE44768
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Summary for Patent: RE44768
| Title: | Rapamycin hydroxyesters |
| Abstract: | A compound of the structure ##STR00001## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen or --CO(CR.sup.3R.sup.4).sub.b(CR.sup.5R.sup.6).sub.dCR.sup.7R.sup.8R.sup.9; R.sup.3 and R.sup.4 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, trifluoromethyl, or --F; R.sup.5 and R.sup.6 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, --(CR.sup.3R.sup.4).sub.fOR.sup.10, --CF.sub.3, --F, or --CO.sub.2R.sup.11, or R.sup.5 and R.sup.6 may be taken together to form X or a cycloalkyl ring that is optionally mono-, di-, or tri-substituted with --(CR.sup.3R.sup.4).sub.fOR.sup.10; R.sup.7 is hydrogen, alkyl, alkenyl, alkynyl, --(CR.sup.3R.sup.4-).sub.fOR.sup.10, --CF.sub.3, --F, or CO.sub.2R.sup.11; R.sup.8 and R.sup.9 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, --(CR.sup.3R.sup.4).sub.fOR.sup.10, --CF.sub.3, --F, or --CO.sub.2R.sup.11, or R.sup.8 and R.sup.9 may be taken together to form X or a cycloalkyl ring that is optionally mono-, di-, or tri-substituted with --(CR.sup.3R.sup.4-).sub.fOR.sup.10; R.sup.10 is hydrogen, alkyl, alkenyl, alkynyl, tri-(alkyl)silyl, tri-(alkyl)silylethyl, triphenylmethyl, benzyl, alkoxymethyl, tri-(alkyl)silylethoxymethyl, chloroethyl, or tetrahydropyranyl; R.sup.11 is hydrogen, alkyl, alkenyl, alkynyl, or phenylalkyl; X is 5-(2,2-dialkyl)[1,3]dioxanyl, 5-(2,2-dicycloalkyl)[1,3]dioxanyl, 4-(2,2-dialkyl)[1,3]dioxanyl, 4-(2,2-dicycloalkyl)[1,3]dioxanyl, 4-(2,2dialkyl)[1,3]dioxalanyl, or 4-(2,2-dicycloalkyl)[1,3]dioxalanyl; b=0-6; d=0-6; and f=0-6 with the proviso that R.sup.1 and R.sup.2 are both not hydrogen and further provided that either R.sup.1 or R.sup.2 contains at least one --(CR.sup.3R.sup.4).sub.fOR.sup.10, X, or --(CR.sup.3R.sup.4).sub.fOR.sup.10 substituted cycloalkyl group, or a pharmaceutically acceptable salt thereof which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent. |
| Inventor(s): | Skotnicki; Jerauld S. (Allentown, NJ), Leone; Christina L. (Princeton, NJ), Schiehser; Guy A. (Yardley, PA) |
| Assignee: | Wyeth LLC (Madison, NJ) |
| Application Number: | 13/931,400 |
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Patent Claim Types: see list of patent claims | Compound; Use; Composition; |
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Drugs Protected by US Patent RE44768
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
International Family Members for US Patent RE44768
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| European Patent Office | 0763039 | ⤷ Subscribe | CA 2008 00028 | Denmark | ⤷ Subscribe |
| European Patent Office | 0763039 | ⤷ Subscribe | 91438 | Luxembourg | ⤷ Subscribe |
| European Patent Office | 0763039 | ⤷ Subscribe | PA2008009 | Lithuania | ⤷ Subscribe |
| European Patent Office | 0763039 | ⤷ Subscribe | 300348 | Netherlands | ⤷ Subscribe |
| European Patent Office | 0763039 | ⤷ Subscribe | PA2008009,C0763039 | Lithuania | ⤷ Subscribe |
| European Patent Office | 0763039 | ⤷ Subscribe | SPC017/2008 | Ireland | ⤷ Subscribe |
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
