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Last Updated: December 22, 2024

METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE Drug Patent Profile


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When do Metoprolol Tartrate And Hydrochlorothiazide patents expire, and when can generic versions of Metoprolol Tartrate And Hydrochlorothiazide launch?

Metoprolol Tartrate And Hydrochlorothiazide is a drug marketed by Alembic, Mylan, and Sun Pharm Inds. and is included in three NDAs.

The generic ingredient in METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE is hydrochlorothiazide; metoprolol tartrate. There are thirty-two drug master file entries for this compound. Five suppliers are listed for this compound. Additional details are available on the hydrochlorothiazide; metoprolol tartrate profile page.

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Summary for METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE
Drug patent expirations by year for METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE
Recent Clinical Trials for METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE

Identify potential brand extensions & 505(b)(2) entrants

SponsorPhase
Mylan PharmaceuticalsPhase 1
Vanderbilt University Medical CenterPhase 1
Vanderbilt UniversityPhase 1

See all METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE clinical trials

Pharmacology for METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE

US Patents and Regulatory Information for METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Alembic METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE hydrochlorothiazide; metoprolol tartrate TABLET;ORAL 202870-001 Nov 6, 2013 AB RX No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Sun Pharm Inds METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE hydrochlorothiazide; metoprolol tartrate TABLET;ORAL 090654-001 Jan 19, 2012 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Mylan METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE hydrochlorothiazide; metoprolol tartrate TABLET;ORAL 076792-001 Aug 20, 2004 AB RX No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Sun Pharm Inds METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE hydrochlorothiazide; metoprolol tartrate TABLET;ORAL 090654-002 Jan 19, 2012 DISCN No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Alembic METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE hydrochlorothiazide; metoprolol tartrate TABLET;ORAL 202870-002 Nov 6, 2013 AB RX No Yes ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Alembic METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE hydrochlorothiazide; metoprolol tartrate TABLET;ORAL 202870-003 Nov 6, 2013 AB RX No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
Mylan METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE hydrochlorothiazide; metoprolol tartrate TABLET;ORAL 076792-003 Aug 20, 2004 AB RX No No ⤷  Subscribe ⤷  Subscribe ⤷  Subscribe
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE Market Analysis and Financial Projection Experimental

Metoprolol Tartrate and Hydrochlorothiazide Market Dynamics and Financial Trajectory

Market Overview

Metoprolol tartrate and hydrochlorothiazide are commonly used in combination to treat hypertension (high blood pressure) and other cardiovascular conditions. This combination therapy leverages the beta-blocking properties of metoprolol tartrate and the diuretic effects of hydrochlorothiazide to effectively manage blood pressure.

Market Size and Growth

The global metoprolol tartrate market, which includes its combination with hydrochlorothiazide, is projected to experience significant growth over the coming years. By 2027, the metoprolol tartrate market is estimated to reach $868.3 million, growing at a CAGR of 5.2% during the forecast period 2022-2027[1].

For the broader period up to 2031, the market is expected to grow from $6,553.01 million in 2023 to $8,805.36 million, with a CAGR of 3.8%[3].

Drivers of Market Growth

Increasing Prevalence of Cardiovascular Diseases

The rising incidence of cardiovascular diseases, including hypertension and heart attacks, is a major driver of the metoprolol tartrate and hydrochlorothiazide market. As the global population ages and lifestyle factors contribute to increased cardiovascular risks, the demand for these medications is expected to rise[3][4].

Patient Education and Adherence

Investments in patient education and adherence programs can improve patient outcomes and loyalty, further driving the market growth. By helping patients understand the importance of adhering to their medication regimens, healthcare providers and pharmaceutical companies can enhance the effectiveness of these treatments[3].

Collaboration with Healthcare Providers

Building collaborative relationships with healthcare providers, hospitals, and clinics can secure preferred formulary status for metoprolol tartrate and hydrochlorothiazide, ensuring their inclusion in treatment protocols. This strategic collaboration is expected to boost market growth[3].

Regional Analysis

North America

North America holds the largest market share for metoprolol tartrate, driven by the high prevalence of heart diseases in this region. In 2021, North America accounted for 36% of the overall metoprolol tartrate market, and it is expected to continue dominating the market due to the increasing incidence of hypertension and other cardiovascular conditions[1][4].

Asia-Pacific

The Asia-Pacific region is expected to be the fastest-growing segment during the forecast period. The increasing application of metoprolol tartrate to treat hypertension and angina, along with growing regional investments in healthcare, is driving this growth[1][3].

Route of Administration

Oral Administration

The oral route of administration dominates the market due to the growing demand for tablets. Metoprolol tartrate and hydrochlorothiazide tablets are widely used for their convenience and effectiveness in managing blood pressure and other cardiovascular conditions[3].

Injectable Form

Metoprolol tartrate injections are also used, particularly in the early stages of heart attacks to minimize mortality. This segment is expected to grow due to its critical role in emergency cardiac care[1].

Challenges and Restraints

Side Effects and Withdrawal Symptoms

The use of metoprolol tartrate can be associated with side effects such as general malaise, palpitations, headache, sweating, and tremor, especially upon abrupt withdrawal. These symptoms can deter some patients from adhering to their treatment plans[2].

Government Regulations and Product Recalls

Stringent government regulations and occasional product recalls can hamper market growth. For instance, recalls due to contamination or other quality issues can impact consumer trust and market dynamics[4].

Healthcare System Reimbursement

Challenges related to reimbursement from healthcare systems can also act as a restraint. Variations in reimbursement policies across different regions can affect the accessibility and affordability of these medications[3].

Competitive Landscape

The market for metoprolol tartrate and hydrochlorothiazide is competitive, with several key players adopting strategies such as product launches, expansions, partnerships, and collaborations to enhance their market share. Companies like Mylan N.V have introduced new strengths of metoprolol tartrate tablets, expanding the treatment options available to patients[4].

Impact of COVID-19

The COVID-19 pandemic has had a mixed impact on the market. On one hand, research into the use of metoprolol tartrate for treating COVID-19-associated complications has opened new avenues for its application. For example, studies have shown that intravenous metoprolol can reduce lung inflammation and improve oxygenation in patients with COVID-19-associated Acute Respiratory Distress Syndrome (ARDS)[4].

Key Takeaways

  • The metoprolol tartrate market is expected to grow significantly due to the increasing prevalence of cardiovascular diseases.
  • North America and the Asia-Pacific region are key markets, driven by high demand for hypertension treatments.
  • Oral administration remains the dominant route, but injectable forms are crucial in emergency cardiac care.
  • Side effects, government regulations, and reimbursement challenges are significant restraints.
  • The COVID-19 pandemic has introduced new potential uses for metoprolol tartrate.

FAQs

1. What is the primary use of metoprolol tartrate and hydrochlorothiazide?

Metoprolol tartrate and hydrochlorothiazide are primarily used to treat hypertension (high blood pressure) and other cardiovascular conditions such as angina and heart attacks.

2. What is the projected market size for metoprolol tartrate by 2027?

The metoprolol tartrate market is estimated to reach $868.3 million by 2027, growing at a CAGR of 5.2% during the forecast period 2022-2027[1].

3. Which region dominates the metoprolol tartrate market?

North America holds the largest market share for metoprolol tartrate, driven by the high prevalence of heart diseases in this region[1][4].

4. What are the common side effects of metoprolol tartrate?

Common side effects include general malaise, palpitations, headache, sweating, and tremor, especially upon abrupt withdrawal of the medication[2].

5. How has the COVID-19 pandemic impacted the metoprolol tartrate market?

The pandemic has introduced new potential uses for metoprolol tartrate, such as treating COVID-19-associated ARDS, but also presented challenges related to product recalls and healthcare system reimbursements[4].

Cited Sources:

  1. IndustryARC, Metoprolol Tartrate Market Size Report, 2022-2027.
  2. PubMed, Comparison of metoprolol and hydrochlorothiazide in 20 patients with mild hypertension.
  3. Data Bridge Market Research, Global Metoprolol Tartrate Market Size, Evaluating Share & Forecast By 2031.
  4. Coherent Market Insights, Metoprolol Tartrate Market Size, Trends and Forecast to 2030.

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