Drugs in ATC Class A09AB

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Up to A - Alimentary tract and metabolism

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Up to A09A - DIGESTIVES, INCL. ENZYMES

Drugs in ATC Class: A09AB - Acid preparations

Tradename	Generic Name
IRRIGATING SOLUTION G IN PLASTIC CONTAINER	citric acid; magnesium oxide; sodium carbonate
PHEXXI	citric acid; lactic acid; potassium bitartrate
PREPOPIK	citric acid; magnesium oxide; sodium picosulfate
RENACIDIN	citric acid; gluconolactone; magnesium carbonate
SODIUM PICOSULFATE, MAGNESIUM OXIDE AND ANHYDROUS CITRIC ACID	citric acid; magnesium oxide; sodium picosulfate
UROLOGIC G IN PLASTIC CONTAINER	citric acid; magnesium oxide; sodium carbonate

A09AB Market Analysis and Financial Projection

The ATC Class A09AB encompasses acid preparations used for digestive purposes, with key agents including citric acid (A09AB04), glutamic acid hydrochloride (A09AB01), betaine hydrochloride (A09AB02), and hydrochloric acid (A09AB03). These compounds play critical roles in regulating pH, enhancing digestion, and serving as preservatives in pharmaceuticals and food industries. Below is an analysis of their market dynamics and patent landscape:

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Market Dynamics

Growth Drivers

• Demand in Food & Beverage: Citric acid dominates the global acidity regulators market (valued at $7.34 billion in 2023), driven by its use in beverages, processed foods, and dairy products[4][11]. Phosphoric acid and lactic acid follow, with the latter gaining traction in yogurt and cheese production[4].
• Pharmaceutical Applications: Citric acid is widely used in blood collection tubes, drug formulations (e.g., anticoagulants), and as an excipient. Glutamic acid hydrochloride is utilized in gastroprotective preparations[5][8].
• Regional Expansion: Asia-Pacific leads the market due to rising populations, disposable incomes, and food industry growth in India and China. North America remains a key innovator, with companies like Cargill and ADM expanding production capacities[4][11].

Challenges

• Raw Material Volatility: Price fluctuations in biomass, corn, and synthetic gases impact production costs for organic acids like citric acid[11].
• Regulatory Compliance: Stricter environmental regulations on manufacturing processes and waste management increase operational costs[14].

Innovation Trends

• Collaborative R&D: BASF and Solvay partnered in 2023 to develop advanced pH regulators for industrial applications, enhancing efficiency in sectors like agriculture and chemicals[4].
• Eco-Friendly Solutions: Growing emphasis on bio-based acids and green chemistry to meet sustainability goals[11].

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Patent Landscape

Key Technological Focus Areas

1. Formulation Patents:
   • Citric acid patents cover applications in anticoagulants (e.g., CITRAVESCENT for renal tubular acidosis)[8], preservatives, and acidifying agents[5].
   • Grazoprevir-related patents highlight processes for stabilizing formulations using citric acid derivatives[9].
2. AI Integration: Near-infrared spectroscopy patents (e.g., by Life Technologies and Nvidia) incorporate AI for real-time analysis of acid interactions in pharmaceuticals[2].
3. Device-Specific Patents: Innovations in portable diagnostic tools and drug delivery systems leveraging acid preparations for pH control[2][12].

Regional Patent Activity

• U.S. Leadership: Over 800 patents in spectroscopy and acid-based formulations, led by companies like Purdue Pharma and Cilag GmbH[2].
• Asia-Pacific Growth: Surge in patents for citric acid extraction technologies and biodegradable formulations, particularly in China and India[11].

Strategic Insights

• Portfolio Diversification: Companies like Kerry Group and Archer Daniels Midland focus on securing patents for multi-enzyme/acid combinations (e.g., A09AC02)[15].
• Litigation Risks: Overlapping patents in nanotechnology and acid stabilization methods could lead to disputes, emphasizing the need for thorough freedom-to-operate analyses[6][12].

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Market Outlook

The global acidity regulators market is projected to grow at a 4.81% CAGR through 2029, reaching $989.8 million for spectroscopy-linked applications[2][4]. Citric acid will remain pivotal due to its versatility, while advancements in AI-driven formulation optimization and sustainable production methods will shape future R&D. Key opportunities lie in addressing regulatory hurdles and expanding into emerging markets with tailored acid solutions[4][11].

"The integration of AI and eco-friendly manufacturing is revolutionizing acid preparation technologies, offering precision and sustainability." — ResearchAndMarkets.com[2].

References

1. https://www.tglobaltechnology.com/product/tg-s09ab-potting-compound/
2. https://www.globenewswire.com/news-release/2025/03/14/3043095/28124/en/Comprehensive-Near-Infrared-Spectroscopy-Patent-Landscape-Report-Reveals-Market-to-Reach-USD-989-8-Million-by-2032.html
3. https://pubchem.ncbi.nlm.nih.gov/compound/Citric-Acid
4. https://www.techsciresearch.com/report/acidity-regulators-market/21161.html
5. https://go.drugbank.com/drugs/DB04272
6. https://www.knowmade.com/patent-analytics-services/patent-report/life-sciences-patent-landscape/allogeneic-car-patent-landscape-analysis-2023/
7. https://go.drugbank.com/drugs/DB00142
8. https://www.rxreasoner.com/drugs/citravescent
9. https://unitaid.org/uploads/Grazoprevir_Patent_Landscape.pdf
10. https://www.globenewswire.com/news-release/2024/11/08/2977421/28124/en/Ammonia-Market-Global-Forecast-Report-to-2029-Featuring-Green-Ammonia-Impact-Assessment-Case-Study.html
11. https://www.fortunebusinessinsights.com/organic-acids-market-102442
12. https://medicinespatentpool.org/uploads/2020/04/MPP-Unitaid_Intellectual-property-report-on-long-acting-technologies.pdf
13. https://www.globenewswire.com/news-release/2024/08/15/2930740/28124/en/Global-Battery-Energy-Storage-System-Market-Forecast-to-2029-Increasing-Opportunities-in-Rural-Electrification-Projects-Worldwide-and-Rising-Demand-for-Power-Supply-from-Data-Cente.html
14. https://www.coherentmarketinsights.com/industry-reports/sulfamic-acid-market
15. https://prediction.charite.de/subpages/tree.php
16. https://www.ipcheckups.com/patent-landscape-analysis-how-to-5-steps/
17. https://www.iiprd.com/patent-technology-landscape-analysis/