Drugs in ATC Class B05CB

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Up to B - Blood and blood forming organs

Up to B05 - BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS

Up to B05C - IRRIGATING SOLUTIONS

Drugs in ATC Class: B05CB - Salt solutions

Tradename	Generic Name
AMINOSYN II 3.5% W/ ELECTROLYTES IN DEXTROSE 25% W/ CALCIUM IN PLASTIC CONTAINER	amino acids; calcium chloride; dextrose; magnesium chloride; potassium chloride; potassium phosphate, dibasic; sodium chloride
AMINOSYN II 4.25% W/ ELECTROLYTES IN DEXTROSE 20% W/ CALCIUM IN PLASTIC CONTAINER	amino acids; calcium chloride; dextrose; magnesium chloride; potassium chloride; potassium phosphate, dibasic; sodium chloride
AMINOSYN II 4.25% W/ ELECTROLYTES IN DEXTROSE 25% W/ CALCIUM IN PLASTIC CONTAINER	amino acids; calcium chloride; dextrose; magnesium chloride; potassium chloride; potassium phosphate, dibasic; sodium chloride
AMINOSYN II 5% W/ ELECTROLYTES IN DEXTROSE 25% W/ CALCIUM IN PLASTIC CONTAINER	amino acids; calcium chloride; dextrose; magnesium chloride; potassium chloride; potassium phosphate, dibasic; sodium chloride
CLINIMIX E 2.75/10 SULFITE FREE W/ ELECT IN DEXTROSE 10% W/ CALCIUM IN PLASTIC CONTAINER	amino acids; calcium chloride; dextrose; magnesium chloride; potassium phosphate, dibasic; sodium acetate; sodium chloride
CLINIMIX E 2.75/25 SULFITE FREE W/ ELECT IN DEXTROSE 25% W/ CALCIUM IN PLASTIC CONTAINER	amino acids; calcium chloride; dextrose; magnesium chloride; potassium phosphate, dibasic; sodium acetate; sodium chloride
PROCALAMINE	amino acids; calcium acetate; glycerin; magnesium acetate; phosphoric acid; potassium chloride; sodium acetate; sodium chloride

B05CB Market Analysis and Financial Projection

The market dynamics and patent landscape for ATC Class B05CB (Salt Solutions) reflect a sector driven by healthcare demands, innovation in medical formulations, and strategic intellectual property (IP) management. Here's a detailed analysis:

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Market Dynamics

Growth Drivers

• Surgical and Clinical Demand: Sodium chloride irrigation solutions, a key component of B05CB, are projected to grow from USD 1.5 billion (2022) to USD 2.5 billion by 2030 (CAGR 7.0%), driven by rising surgical volumes and chronic disease prevalence[11][14].
• Aging Population: Increased hospitalization and surgical needs among elderly populations are amplifying demand[11].
• Industrial and Healthcare Expansion: The global salt market is booming, with a forecasted rise from $45.74 billion (2024) to $68.06 billion by 2029, driven by food processing, mining, and medical applications[9][12].

Challenges

• Regulatory Hurdles: Strict manufacturing standards and compliance requirements slow market entry[11][14].
• Supply Chain Vulnerabilities: Raw material shortages and logistics disruptions impact production costs[9][14].

Opportunities

• Emerging Markets: Asia-Pacific and Latin America offer untapped potential due to expanding healthcare infrastructure[11][14].
• Innovative Formulations: Smart saline solutions and eco-friendly packaging are emerging trends in irrigation products[11][14].

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Patent Landscape

Key Innovations

• Crystal Morphology: Patents like US10881123B2 focus on salt crystal engineering to enhance perceived saltiness, reducing sodium content in medical and food products[17].
• Production Methods: Techniques for efficient salt crystallization (e.g., US8888867) and recycling brine in manufacturing processes[18].
• Drug Formulations: Sodium bicarbonate (B05CB04) and sodium citrate (B05CB02) dominate IP activity, with applications in metabolic acidosis treatment and anticoagulation[1][6][8].

Competitive IP Strategies

• Market Leaders: Companies like Hospira, Baxter, and Fresenius hold multiple NDAs and Drug Master Files for intravenous and irrigating salt solutions[1][6][11].
• Technology Segmentation: Patent filings emphasize trench MOSFETs in semiconductor packaging and sustainable production methods, though these intersect indirectly with medical salt solutions[13][16].

Trends

• Strategic Filings: Accelerated patenting in combination therapies (e.g., sodium bicarbonate with psycholeptics) and sterile saline solutions[4][8].
• Global IP Expansion: Companies prioritize filings in the U.S., China, and Europe to protect market share[10][13].

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Key Players and Products

Company	Product	Application	Key Patent/NDA
Hospira	Sodium Bicarbonate Injection	Metabolic acidosis treatment	NDA 077394-001[1]
Baxter	0.45% Sodium Chloride	Hydration and renal function assessment	DrugBank DB09153[5][14]
Fresenius	Bibag Irrigation Solution	Dialysis and surgical irrigation	EU Patent EP3090766B1[6]

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Future Outlook

• Technological Integration: Advances in smart irrigation systems and biodegradable packaging will shape the next decade[11][14].
• Regulatory Collaboration: Harmonizing global standards (e.g., FDA, WHO) could streamline market access[12][16].

"The growth of salt solutions in healthcare underscores their critical role in surgical outcomes and chronic disease management." – Industry Report[14].

This sector’s growth hinges on balancing innovation with regulatory compliance, while IP strategies will focus on safeguarding novel formulations and production efficiencies.

References

1. https://www.drugpatentwatch.com/p/generic-api/SODIUM+BICARBONATE
2. https://atcddd.fhi.no/filearchive/publications/2025_guidelines__final_web.pdf
3. https://atcddd.fhi.no/atc_ddd_index/?code=b05cb01
4. https://atcddd.fhi.no/atc_ddd_index/?code=B05CB&showdescription=yes
5. https://www.pharmacompass.com/chemistry-chemical-name/sodium-chloride-usp-crystal-grade
6. https://go.drugbank.com/drugs/DB01390
7. https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-Bicarbonate
8. https://go.drugbank.com/drugs/DB09154
9. https://www.thebusinessresearchcompany.com/report/salt-global-market-report
10. https://www.knowmade.com/patent-analytics-services/patent-report/semiconductor-patent-landscape/semiconductor-advanced-packaging-patent-landscape/hybrid-bonding-patent-landscape-analysis-2024/
11. https://sites.google.com/view/innova-research/home/reports/sodium-chloride-irrigation-solution-market-analysis-current-landscape-and
12. https://www.businesswire.com/news/home/20250321110344/en/United-States-Salt-Industry-Report-2025-Market-Review-2019-2024-and-Forecasts-2025-2029---SupplyDemand-Trade-Statistics-Production-Consumption---ResearchAndMarkets.com
13. https://www.knowmade.com/patent-analytics-services/patent-report/semiconductor-patent-landscape/power-electronics-devices-patent-landscape/silicon-carbide-sic-patent-landscape-analysis-2024/
14. https://www.verifiedmarketreports.com/product/sodium-chloride-irrigation-solution-market/
15. https://www.acclaimip.com/patent-landscaping/patent-landscape-analysis-uncovering-strategic-insights/
16. https://ip.com/blog/2025-patent-trends-challenges-and-innovations-shaping-the-future-of-technology/
17. https://patents.google.com/patent/US10881123B2/en
18. https://patents.justia.com/patents-by-us-classification/23/303