Ofatumumab and Bendamustine Hydrochloride With or Without Bortezomib in Treating Patients With Untreated Follicular Non-Hodgkin Lymphoma
Active, not recruiting
National Cancer Institute (NCI)
Phase 2
2011-04-08
This randomized phase II trial studies how well ofatumumab and bendamustine hydrochloride
with or without bortezomib works in treating patients with untreated follicular non-Hodgkin
lymphoma. Monoclonal antibodies, such as ofatumumab, may block cancer growth in different
ways by targeting certain cells. Drugs used in chemotherapy, such as bendamustine
hydrochloride, work in different ways to stop the growth of cancer cells, either by killing
the cells, by stopping them from dividing, or by stopping them from spreading. Bortezomib may
stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Bortezomib may also stop the growth of cancer cells by blocking blood flow to the tumor. It
is not yet known whether ofatumumab and bendamustine hydrochloride are more effective with
bortezomib in treating patients with follicular non-Hodgkin lymphoma.
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