A Study to Evaluate the Preliminary Efficacy Pharmacokinetics and Immunogenicity of BMS-188667 Administered to Subjects With Relapsing-remitting Multiple Sclerosis
Terminated
Bristol-Myers Squibb
Phase 2
2001-11-01
The purpose of this study is to determine whether BMS-188667 will decrease multiple sclerosis
disease activity on MRI examinations, as well as decrease the rate of clinical MS
exacerbations, compared to placebo
Phase III Study of BMS-188667 (CTLA4Ig) in Patients With Rheumatoid Arthritis Who Are Currently Failing Anti-TNF Therapy or Who Have Failed Anti-TNF Therapy in the Past.
Completed
Bristol-Myers Squibb
Phase 3
2002-12-01
The purpose of this clinical research study is to determine whether abatacept treatment on a
background of Disease Modifying Antirheumatic Drugs (DMARDs) will relieve the symptoms of
rheumatoid arthritis (RA) in participants who are currently receiving anti-tumor necrosis
factor (TNF) therapy for at least 3 months and are not responding or have taken anti-TNF
therapy in the last 3 months and did not respond. The safety of treatment with abatacept will
also be evaluated. This study also has a 4.5-year long-term extension beginning 6 months
after the start of the study.
A Phase III Study of BMS-188667 in Subjects With Active Rheumatoid Arthritis
Completed
Bristol-Myers Squibb
Phase 3
2002-12-01
The purpose of this clinical research study is to learn if abatacept is safe when
co-administered with other approved rheumatoid arthritis medications.
Abatacept and Infliximab in Combination With Methotrexate in Subjects With Rheumatoid Arthritis
Completed
Bristol-Myers Squibb
Phase 3
2005-02-01
The purpose of this clinical research study is to learn if Abatacept or Infliximab in
combination with Methotrexate demonstrate a greater reduction in disease activity over
placebo.
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