Serologic Response to SHINGRIX Vaccine in Patients With CLL and WM Treated With BTK Inhibitors
Active, not recruiting
University of Rochester
Early Phase 1
2019-02-01
The primary objective of the study is to assess the capability of a patient with Chronic
Lymphocytic Leukemia (CLL) or Waldenström Macroglobulinemia (WM) to generate an immune
response to the Shingrix vaccine under first-line BTK inhibitors.
Training the Innate Immune System Against SARS-CoV-2 (COVID-19) Using the Shingrix Vaccine in Nursing Home Residents
Recruiting
Oklahoma Medical Research Foundation
Early Phase 1
2020-09-01
The purpose of this study is to measure the effect of the Shingrix vaccine on your immune
system and whether that has any effect on the body's ability to fight off other infections
such as COVID-19. We hypothesize that:
H1: Shingrix vaccination will elevate acute and trained immunity
H2: For 6 months following the first injection, increased levels of acute and trained
immunity is associated with less disease, including fewer hospitalizations and deaths
associated with flu, pneumonia, and COVID-19.
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