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Last Updated: July 16, 2024

CLINICAL TRIALS PROFILE FOR GLUCARPIDASE

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All Clinical Trials for glucarpidase

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Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00018967 ↗	Carboxypeptidase-G2 in Treating Nervous System Toxic Effects in Patients Given an Overdose of Intrathecal Methotrexate	Completed	Children's Oncology Group	N/A	1993-11-01	RATIONALE: Chemoprotective drugs such as carboxypeptidase-G2 may protect normal cells from the toxic effects of chemotherapy. PURPOSE: Clinical trial to study the effectiveness of carboxypeptidase-G2 in treating nervous system toxic effects in patients given an accidental overdose of intrathecal methotrexate.
NCT00018967 ↗	Carboxypeptidase-G2 in Treating Nervous System Toxic Effects in Patients Given an Overdose of Intrathecal Methotrexate	Completed	National Cancer Institute (NCI)	N/A	1993-11-01	RATIONALE: Chemoprotective drugs such as carboxypeptidase-G2 may protect normal cells from the toxic effects of chemotherapy. PURPOSE: Clinical trial to study the effectiveness of carboxypeptidase-G2 in treating nervous system toxic effects in patients given an accidental overdose of intrathecal methotrexate.
NCT00219791 ↗	Study of Glucarpidase (CPG2) for the Management of Patients With Delayed Methotrexate Clearance	Completed	BTG International Inc.	Phase 2	2000-01-01	To evaluate the safety and efficacy of glucarpidase in patients with impaired methotrexate (MTX) clearance owing to MTX-induced renal failure following high-dose MTX therapy, or with intrathecal MTX overdose.
>Trial ID	>Title	>Status	>Sponsor	>Phase	>Start Date	>Summary

Clinical Trial Conditions for glucarpidase

Condition Name

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Condition Name for glucarpidase
Intervention	Trials
Osteosarcoma	3
Lymphoma	2
Neurotoxicity	2
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Condition MeSH

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Condition MeSH for glucarpidase
Intervention	Trials
Lymphoma	4
Osteosarcoma	3
Neurotoxicity Syndromes	2
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Clinical Trial Locations for glucarpidase

Trials by Country

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Trials by Country for glucarpidase
Location	Trials
United States	49
Canada	7
United Kingdom	2
Australia	2
Iceland	1
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Trials by US State

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Trials by US State for glucarpidase
Location	Trials
Pennsylvania	3
New York	3
Minnesota	2
Florida	2
Texas	2
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Clinical Trial Progress for glucarpidase

Clinical Trial Phase

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Clinical Trial Phase for glucarpidase
Clinical Trial Phase	Trials
Phase 3	1
Phase 2	5
Phase 1/Phase 2	2
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Clinical Trial Status

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Clinical Trial Status for glucarpidase
Clinical Trial Phase	Trials
Recruiting	4
Completed	4
Terminated	3
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Clinical Trial Sponsors for glucarpidase

Sponsor Name

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Sponsor Name for glucarpidase
Sponsor	Trials
BTG International Inc.	6
University College, London	2
National Cancer Institute (NCI)	2
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Sponsor Type

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Sponsor Type for glucarpidase
Sponsor	Trials
Other	25
NIH	2
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