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Last Updated: December 26, 2024

Fibrin sealant (tisseel) - Biologic Drug Details


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Summary for fibrin sealant (tisseel)
Tradenames:1
High Confidence Patents:0
Applicants:1
BLAs:1
Suppliers: see list1
Pharmacology for fibrin sealant (tisseel)
Note on Biologic Patents

Matching patents to biologic drugs is far more complicated than for small-molecule drugs.

DrugPatentWatch employs three methods to identify biologic patents:

  1. Brand-side disclosures in response to biosimilar applications
  2. These patents were identified from disclosures by the brand-side company, in response to a potential biosimilar seeking to launch. They have a high certainty of blocking biosimilar entry. The expiration dates listed are not estimates — they're expiration dates as indicated by the brand-side company.

  3. General brand-side disclosures
  4. These patents were identified from searching drug labels and other general disclosures from the brand-side company. This list may exclude some of the patents which block biosimilar launch, and some of these patents listed may not actually block biosimilar launch. The expiration dates listed for these patents are estimates, based on the grant date of the patent.

  5. Patents from broad patent text search
  6. For completeness, these patents were identified by searching the patent literature for mentions of the branded or ingredient name of the drug. Some of these patents protect the original drug, whereas others may protect follow-on inventions or even inventions casually mentioning the drug. The expiration dates listed for these patents are estimates, based on the grant date of the patent.

1) High Certainty: US Patents for fibrin sealant (tisseel) Derived from Brand-Side Litigation

No patents found based on brand-side litigation

2) High Certainty: US Patents for fibrin sealant (tisseel) Derived from Company Disclosures

No patents found based on company disclosures

3) Low Certainty: US Patents for fibrin sealant (tisseel) Derived from Patent Text Search

No patents found based on company disclosures

Fibrin sealant (tisseel) Market Analysis and Financial Projection Experimental

Fibrin Sealants Market: Dynamics and Financial Trajectory

Introduction to Fibrin Sealants

Fibrin sealants, such as Tisseel, are biologic products used to manage bleeding during surgeries and traumatic injuries. These sealants typically consist of fibrinogen and thrombin, which are essential components in the blood clotting process. Here, we delve into the market dynamics and financial trajectory of the fibrin sealants market.

Market Size and Growth Projections

The global fibrin sealants market is experiencing significant growth, driven by increasing surgical procedures and the rising prevalence of chronic diseases.

  • By 2032, the market is expected to reach approximately USD 2,561.1 million, growing from USD 1,306.1 million in 2023 at a CAGR of 8.0%[1].
  • Another projection indicates the market will reach USD 1.92 billion by 2033, growing at a CAGR of 7% from its current value of USD 976.5 million[3].
  • The market is also forecasted to reach USD 2 billion by 2031, growing at a CAGR of around 7% from 2021[5].

Segmentation by Type

Fibrin sealants are primarily categorized into two types:

Liquid Fibrin Sealants

  • Liquid fibrin sealants are the largest contributors to the market and are expected to continue growing throughout the forecast period. They are preferred for their ease of application and effectiveness in managing bleeding during surgeries[1][3][4].

Patch Fibrin Sealants

  • Patch fibrin sealants, which include collagen or cellulose patches, are also gaining traction. These patches are flexible and can be implanted with fibrinogen and thrombin to achieve hemostasis. The demand for patch fibrin sealants is expected to grow at a CAGR of 6.5% over the next decade[3].

Application Segments

Fibrin sealants are used across various surgical disciplines:

Cardiovascular Surgery

  • This segment dominates the market, accounting for approximately 48% of the revenue share. The high prevalence of cardiovascular diseases and the increasing number of coronary bypass grafting (CABG) procedures drive this segment[1][4].

Other Surgical Disciplines

  • Other significant application areas include thoracic surgery, orthopedic surgery, neurosurgery, and dental surgery. These segments are also expected to grow due to the increasing need for effective hemostatic agents[4].

End-User Analysis

The market can be segmented by end-users as follows:

Hospitals

  • Hospitals are the most dominant segment, driven by the high volume of surgical procedures, including CABG and other cardiological surgeries. The hospital segment is expected to continue its dominance during the forecast period[1][4].

Specialty Clinics and Ambulatory Surgical Centers

  • Specialty clinics and ambulatory surgical centers also contribute to the market, although to a lesser extent. These segments are expected to grow as demand for advanced healthcare facilities increases in both developed and developing countries[1][4].

Regional Analysis

The fibrin sealants market is geographically diverse:

North America

  • North America holds a significant market share, approximately 47% in 2022, due to its well-developed healthcare infrastructure and high prevalence of chronic diseases such as cardiovascular disease and orthopedic conditions[1][4].

Asia-Pacific

  • The Asia-Pacific region is expected to experience the fastest growth, with a CAGR of 6.9% over the forecast period. This growth is driven by increasing healthcare spending, demand for better care, and an aging population susceptible to cardiovascular diseases[1][3][4].

Market Drivers

Several factors are driving the growth of the fibrin sealants market:

Growing Prevalence of Surgeries and Traumatic Injuries

  • The increasing number of surgical procedures and traumatic injuries globally is a significant driver. According to the World Health Organization (WHO), millions of individuals die each year due to unintentional injuries and violence-related injuries[2].

Advancements in Hemostasis Technology

  • Recent improvements in hemostasis technology have led to the development of biocompatible sealants that reduce complexities and support normal tissue movement without restraining organ function[5].

Aging Population and Chronic Diseases

  • The growing geriatric population and the increasing prevalence of chronic diseases, such as cardiovascular diseases, are also boosting market growth[4].

Competitive Landscape

The fibrin sealants market is highly concentrated, with a few major players dominating the market share:

Baxter and Ethicon

  • Companies like Baxter and Ethicon (a division of Johnson & Johnson Services, Inc.) hold the majority of the market share. Baxter is currently the leader in terms of revenue, while Ethicon is expected to increase its market share through strategic partnerships and product introductions[3].

Key Industry Events and Acquisitions

Recent industry events include:

  • Baxter's presentation of Tisseel fibrin sealant hemostatic agents with design improvements at the AORN symposium.
  • Ethicon's acquisition of Takeda's TachoSil Surgical Patch for US$ 400 million in May 2019[3].

Technological Advancements

Technological advancements play a crucial role in the growth of the fibrin sealants market:

Biocompatible Sealants

  • Recent developments have led to the creation of biocompatible sealants that reduce complications and support normal tissue movement, enhancing patient outcomes[5].

Viral Inactivation and Recombinant Production

  • Technologies such as viral inactivation and recombinant production are also contributing to the market growth by ensuring safer and more effective products[4].

COVID-19 Pandemic Impact

The COVID-19 pandemic had a mixed impact on the fibrin sealants market:

  • While the pandemic disrupted supply chains and delayed some surgical procedures, it also accelerated the development and adoption of advanced hemostatic agents to manage bleeding in COVID-19 patients[5].

Key Takeaways

  • The global fibrin sealants market is projected to grow significantly, driven by increasing surgical procedures and the prevalence of chronic diseases.
  • Liquid fibrin sealants are the largest segment and are expected to continue growing.
  • Cardiovascular surgery is the dominant application segment.
  • Hospitals are the primary end-users.
  • North America holds a significant market share, but the Asia-Pacific region is expected to experience the fastest growth.
  • Technological advancements and the growing geriatric population are key drivers.

FAQs

1. What is the expected market size of the global fibrin sealants market by 2032?

The global fibrin sealants market is expected to reach approximately USD 2,561.1 million by 2032[1].

2. Which segment dominates the fibrin sealants market in terms of application?

Cardiovascular surgery is the dominant application segment, accounting for approximately 48% of the revenue share[1][4].

3. Which region is expected to experience the fastest growth in the fibrin sealants market?

The Asia-Pacific region is expected to experience the fastest growth, with a CAGR of 6.9% over the forecast period[1][3][4].

4. What are the primary drivers of the fibrin sealants market?

The primary drivers include the growing prevalence of surgeries and traumatic injuries, advancements in hemostasis technology, and the increasing prevalence of chronic diseases such as cardiovascular diseases[2][5].

5. Which companies are the major players in the fibrin sealants market?

Baxter and Ethicon (a division of Johnson & Johnson Services, Inc.) are the major players dominating the market share[3].

Cited Sources:

  1. Market.us: Fibrin Sealants Market Share, Size, Trends | CAGR of 8.0% [https://market.us/report/fibrin-sealants-market/]
  2. Research Nester: Fibrin Sealants Market Size & Share | Growth Trends 2037 [https://www.researchnester.com/reports/fibrin-sealants-market/4466]
  3. Fact.MR: Fibrin Sealants Market Size, Share, Demand & Trends, 2023 - Fact.MR [https://www.factmr.com/report/fibrin-sealants-market]
  4. IndustryARC: Fibrin Sealants Market Size Report, 2024-2030 - IndustryARC [https://www.industryarc.com/Report/15227/fibrin-sealant-market.html]
  5. Transparency Market Research: Fibrin Sealants Market to reach US$ 2 bn by 2031 [https://www.transparencymarketresearch.com/fibrin-sealants-market.html]

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