Claims for Patent: 10,040,859

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Summary for Patent: 10,040,859

Title:	Methods of treating hemophagocytic lymphohistiocytosis with an IL-33 receptor antibody
Abstract:	Compositions and methods for treating a cytokine release syndrome such as chimeric antigen receptor T-cell cytokine release syndrome or hemophagocytic lymphohistiocytosis are provided.
Inventor(s):	Behrens; Edward M. (West Chester, PA), Rood; Julia E. (Philadelphia, PA), Kambayashi; Taku (Malvern, PA)
Assignee:	The Children\'s Hospital of Philadelphia (Philadelphia, PA) The Trustees of the University of Pennsylvania (Philadelphia, PA)
Application Number:	15/305,272
Patent Claims:	1. A method for inhibiting or treating a cytokine-related disease or disorder in a subject, said method comprising administering to a subject an IL-33 pathway inhibitor, wherein said cytokine-related disease or disorder is hemophagocytic lymphohistiocytosis, and wherein said IL-33 pathway inhibitor is an antibody or fragment thereof immunologically specific for IL-33 receptor (IL-33R). 2. The method of claim 1, wherein said method further comprises administering a hemophagocytic lymphohistiocytosis therapy selected from the group consisting of an immunosuppressant, glucocorticoid, cyclosporine A, etoposide, methotrexate, IL-1 blocking agent, rilonacept, canakinumab, and gevokizumab. 3. The method of claim 1, wherein said method further comprises performing a bone marrow transplant on said subject. 4. The method of claim 1, wherein said hemophagocytic lymphohistiocytosis is familial (primary) hemophagocytic lymphohistiocytosis (FHL). 5. The method of claim 1, wherein said hemophagocytic lymphohistiocytosis is secondary hemophagocytic lymphohistiocytosis (SHLH). 6. The method of claim 1, wherein said hemophagocytic lymphohistiocytosis is malignancy associated hemophagocytic lymphohistiocytosis. 7. The method of claim 1, wherein said antibody or fragment thereof is immunologically specific for the extracellular domain of IL-33R. 8. The method of claim 1, wherein said method comprises administering an antibody immunologically specific for IL-33R to the subject. 9. The method of claim 1, wherein said method comprises administering an antibody immunologically specific for the extracellular domain of IL-33R to the subject.

Details for Patent 10,040,859

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate

Kiniksa Pharmaceuticals (uk), Ltd.	ARCALYST	rilonacept	For Injection	125249	February 27, 2008	10,040,859	2034-04-21
Novartis Pharmaceuticals Corporation	ILARIS	canakinumab	For Injection	125319	June 17, 2009	10,040,859	2034-04-21
Novartis Pharmaceuticals Corporation	ILARIS	canakinumab	Injection	125319	December 22, 2016	10,040,859	2034-04-21
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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