Claims for Patent: 10,835,593

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Summary for Patent: 10,835,593

Title:	Modified anthrax toxin protective antigen
Abstract:	Disclosed is a protective antigen (PA) comprising a PA amino acid sequence, wherein one or more of amino acid residues I207, I210, E654, I656, R659, M662, Y681, and L687, as defined by reference to SEQ ID NO: 1, are, independently, substituted, with the proviso that amino acid residue I207 is not substituted with alanine and amino acid residue I210 is not substituted with alanine. Related compositions, nucleic acids, recombinant expression vectors, host cells, populations of cells, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed.
Inventor(s):	Liu Shi-Hui, Leppla Stephen H., Bugge Thomas H., Wein Alexander N., Peters Diane E., Liu Jie, Chen Kuang-Hua
Assignee:	The United States of America as represented by the Secretary Department of Health and Human Services
Application Number:	US15755341
Patent Claims:

Details for Patent 10,835,593

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Microbix Biosystems Inc.	KINLYTIC	urokinase	For Injection	021846	January 16, 1978	10,835,593	2036-08-25
Emergent Biodefense Operations Lansing Llc	BIOTHRAX	anthrax vaccine adsorbed	Injection	103821	November 12, 1998	10,835,593	2036-08-25
Kedrion Biopharma Inc.	RYPLAZIM	plasminogen, human-tvmh	For Injection	125659	June 04, 2021	10,835,593	2036-08-25
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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