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Last Updated: December 27, 2024

Claims for Patent: 3,933,996

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Summary for Patent: 3,933,996

Title:	Composition comprising radioactive labeled-fibrinogen and albumin
Abstract:	The stability of fibrinogen is improved by mixing it with albumin, preferably at least 5 parts by weight of albumin per part by weight of fibrinogen. By this invention, iodinated (.sup.125 I) human fibrinogen can be stabilised with human serum albumin for use in the diagnosis of thrombi.
Inventor(s):	Charlton; John Cecil (Amersham, EN), Gravett; David Lawrence (Amersham, EN)
Assignee:	The Radiochemical Centre Limited (Amersham, EN)
Application Number:	05/371,529
Patent Claims:	1. A solid product comprising one part by weight of fibrinogen labelled with a radioactive iodine isotope, and from 1 to 1,000 parts by weight of albumin to reduce or prevent unwanted decomposition of the fibrinogen. 2. A solid product as claimed in claim 1, wherein the fibrinogen is labelled with iodine-125. 3. A solid product as claimed in claim 1, wherein the fibrinogen is human fibrinogen and the albumin is human serum albumin. 4. A solid product as claimed in claim 1, containing at least 5 parts by weight of the albumin per part by weight of the fibrinogen. 5. A solid product as claimed in claim 1, containing 20 - 1,000 parts by weight of the albumin per part by weight of the fibrinogen. 6. A method of making the solid product claimed in claim 1, which comprises removing water from an aqueous solution or suspension of one part by weight of the fibrinogen containing from 1 to 1,000 parts by weight of the albumin to reduce or prevent unwanted decomposition of the fibrinogen. 7. A method as claimed in claim 6, wherein the removal of water is effected by freeze-drying. 8. A method as claimed in claim 6, wherein the aqueous solution or suspension contains 20 - 1,000 parts by weight of the albumin per part by weight of the fibrinogen. 9. A solid product comprising fibrinogen iodinated with iodine-125 and from 5 to 1000 parts by weight of albumin per part by weight of fibrinogen, wherein the proportion ##EQU2## remains above 0.5 during storage for one month at 2.degree.C. 10. A solid product as claimed in claim 9, containing 20 - 1,000 parts by weight of the albumin per part by weight of the fibrinogen.

Details for Patent 3,933,996

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5	albumin (human)	For Injection	101138	October 21, 1942	⤷ Subscribe	1993-01-20
Takeda Pharmaceuticals U.s.a., Inc.	BUMINATE, FLEXBUMIN	albumin (human)	Injection	101452	March 03, 1954	⤷ Subscribe	1993-01-20
Csl Behring Ag	ALBURX	albumin (human)	Injection	102366	July 23, 1976	⤷ Subscribe	1993-01-20
Grifols Biologicals Llc	ALBUTEIN	albumin (human)	Injection	102478	August 15, 1978	⤷ Subscribe	1993-01-20
Grifols Biologicals Llc	ALBUTEIN	albumin (human)	Injection	102478	November 29, 2022	⤷ Subscribe	1993-01-20
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	February 17, 1995	⤷ Subscribe	1993-01-20
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	June 11, 2003	⤷ Subscribe	1993-01-20
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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