Claims for Patent: 4,846,835

Summary for Patent: 4,846,835

Title:	Technique for healing lesions in cartilage
Abstract:	A grafting technique entailing the transplantation of chondrocytes for promoting the healing of lesions in articular cartilage, use being made for this purpose of in vitro autologous cultured chondrocytes prior to transplantation. The chondrocytes are preferably seeded in a three-dimensional collagen matrix which serves as the graft material. In order to internally fix the graft during the healing process, use is made of a periosteal flap which is sutured to the cartilage after the graft material is implanted therein.
Inventor(s):	Grande; Daniel A. (Glen Cove, NY)
Assignee:
Application Number:	07/061,952
Patent Claims:	1. A grafting technique for promoting the healing of an articular cartilage lesion comprising the steps of: A: producing in vitro autologous cultured chondrocytes prior to grafting; B: seeding a collagen matrix with the cultured chondrocytes to provide an activated matrix; C: implanting the activated collagen matrix in the lesion to be treated to provide a graft; and D: mechanically fixing the graft by a periosteal flap sutured to the cartilage so that it remains in place during the healing process. 2. A technique as set forth in claim 1, wherein said matrix is a collagen gel. 3. A technique as set forth in claim 1, wherein said matrix is a collagen sponge. 4. A grafting technique as set forth in claim 1, wherein said collagen matrix is constituted by a collagen gel in which the chondrocytes are dispersed prior to its polymerization.

Details for Patent 4,846,835

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Vericel Corporation	CARTICEL SM SERVICE	autologous cultured chondrocytes	Injection	103661	August 22, 1997	4,846,835	2039-02-26
Vericel Corporation	MACI	autologous cultured chondrocytes on porcine collagen membrane	Cell Sheets	125603	December 13, 2016	4,846,835	2039-02-26