Claims for Patent: 5,371,193
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Summary for Patent: 5,371,193
Title: | Mammalian cytokine, IL-11 |
Abstract: | A novel mammalian cytokine, IL-11, and processes for producing it are disclosed. IL-11 may be used in pharmaceutical preparations for stimulating and/or enhancing cells involved in the immune response and cells involved in the proper functioning of the hematopoietic system. |
Inventor(s): | Bennett; Frances K. (Melrose, MA), Paul; Stephen R. (Boston, MA), Yang; Yu-Chung (Indianapolis, IN) |
Assignee: | Genetics Institute, Inc. - Legal Affairs (Cambridge, MA) |
Application Number: | 08/017,522 |
Patent Claims: | 1. Isolated IL-11 having IL-11 activity and comprising an amino acid sequence as set forth in SEQ ID NO: 2 or 4.
2. The protein of claim 1 which is human IL-11. 3. Isolated mature IL-11 having IL-11 activity and encoded by a DNA sequence as in SEQ ID NO: 1 or 3, or a DNA sequence capable of hybridizing thereto under stringent conditions. 4. Isolated mammalian IL-11 having one or more of the following characteristics: (1) an apparent molecular weight under reducing conditions on SDS PAGE of approximately 20 kD; (2) a calculated molecular weight of approximately 20 kD; (3) biological activity in a T1165 assay; (4) biological activity in a megakaryocyte colony forming assay in the presence of IL-3; (5) biological activity on a B cell plaque forming assay. 5. The protein of claim 3 having biological activity in the T1165 assay in the absence of IL-6. 6. The protein of claim 4 produced by: culturing a cell transformed with a DNA sequence encoding expression of an II-11 polypeptide in operative association with an expression control sequence capable of directing the replication and expression of IL-11, and recovering from the conditioned medium thereof an IL-11 protein. 7. The protein of claim 6 wherein said DNA sequence encoding said protein comprises a DNA sequence of SEQ ID NO. 1 or 3, or a DNA sequence capable of hybridizing thereto under stringent conditions. 8. A pharmaceutical composition comprising a therapeutically effective amount of the protein of claim 4 in a pharmaceutically effective vehicle. |
Details for Patent 5,371,193
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Wyeth Pharmaceuticals Inc. | NEUMEGA | oprelvekin | For Injection | 103694 | November 25, 1997 | 5,371,193 | 2011-12-06 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
International Patent Family for US Patent 5,371,193
Country | Patent Number | Estimated Expiration |
---|---|---|
World Intellectual Property Organization (WIPO) | 9107495 | ⤷ Subscribe |
United States of America | 6066317 | ⤷ Subscribe |
United States of America | 5854028 | ⤷ Subscribe |
United States of America | 5700664 | ⤷ Subscribe |
United States of America | 5215895 | ⤷ Subscribe |
Mexico | 9203439 | ⤷ Subscribe |
South Korea | 970005050 | ⤷ Subscribe |
>Country | >Patent Number | >Estimated Expiration |
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