Claims for Patent: 5,409,990

Summary for Patent: 5,409,990

Title:	Complex containing coagulation factor IX
Abstract:	Factor IX is selectively adsorbed by means of hydrophobic chromatography from an aqueous mixture containing at least one plasma zymogen or a vitamin-K dependent protein in addition to factor IX. By this method, the efficient enrichment of factor IX for the production of pharmaceutical preparations has become possible.
Inventor(s):	Linnau; Yendra (Vienna, AT), Sazgary; Maria (Vienna, AT)
Assignee:	Immuno Aktiengesellschaft (Wien, AT)
Application Number:	08/146,921
Patent Claims:	1. A coagulation factor IX complex which comprises a carrier based on a polymer containing hydrophobic groups, to which factor IX is selectively bound from an aqueous mixture containing at least one plasma zymogen in addition to factor IX. 2. A coagulation factor IX complex which comprises a carrier based on a polymer containing hydrophobic groups, to which factor IX is selectively bound from an aqueous mixture containing at least one vitamin-K dependent protein in addition to factor IX. 3. A coagulation factor IX complex as set forth in claim 2, wherein said at least one vitamin-K dependent protein is selected from the group consisting of protein C, protein S and factors II, VII and X. 4. A complex as set forth in claim 2, wherein said factor IX is bound from an aqueous mixture containing prothrombin complex. 5. A complex as set forth in claim 2, wherein said factor IX has an activity that is at least five times higher than that of another vitamin-K dependent protein present in said aqueous mixture. 6. A complex as set forth in claim 1 treated to inactivate possibly present infectious agents. 7. A method for using a coagulation factor IX complex, comprising the steps of: (a) providing a preparation containing coagulation factor IX complex which comprises a carrier based on a polymer containing hydrophobic groups, to which factor IX is selectively bound from an aqueous mixture containing at least one plasma zymogen in addition to factor IX, and (b) using the complex of step (a) for obtaining monoclonal antibodies directed against factor IX. 8. A method for using a coagulation factor IX complex, comprising the steps of: (a) providing a preparation containing coagulation factor IX complex which comprises a carrier based on a polymer containing hydrophobic groups, to which factor IX is selectively bound from an aqueous mixture containing at least one plasma zymogen in addition to factor IX, and (b) using the complex of step (a) for obtaining polyclonal antibodies directed against factor IX.

Details for Patent 5,409,990

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Biologicals Llc	PROFILNINE, PROFILNINE HP, PROFILNINE HT, PROFILNINE SD	factor ix complex	For Injection	102476	July 20, 1981		2012-04-25