Claims for Patent: 5,545,405
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Summary for Patent: 5,545,405
Title: | Method for treating a mammal suffering from cancer with a cho-glycosylated antibody |
Abstract: | The invention relates to a CHO cell-line capable of producing antibody, the cell-line having been co-transfected with a vector capable of expressing the light chain of the antibody and a vector capable of expressing the heavy chain of the antibody wherein the vectors contain independently selectable markers; also included is a CHO cell-line capable of producing a human antibody or an altered antibody, the cell-line having been transfected with a vector capable of expressing the light chain of the antibody and the heavy chain of the antibody; process for the production of antibody using a CHO cell-line and antibody having CHO glycosylation. |
Inventor(s): | Page; Martin J. (Beckenham, GB) |
Assignee: | Burroughs Wellcome Co. (Research Triangle Park, NC) |
Application Number: | 08/335,401 |
Patent Claims: | 1. In a method for treating a human suffering from cancer by administering a therapeutically effective amount of a whole glycosylated recombinant human, chimeric, CDR grafted or
bispecific antibody effective in treating said cancer, wherein the improvement comprises an antibody glycosylated by a Chinese hamster ovary cell.
2. A method in accordance with claim 1, wherein the cancer is non-Hodgkins lymphoma. 3. A method in accordance with claim 1, wherein the cancer is multiple myeloma. 4. A method in accordance with claim 3, wherein the antibody specifically recognizes a T cell marker. 5. A method in accordance with claim 4, wherein the antibody is an anti-CDw52 antibody. 6. A method in accordance with claim 1, wherein the antibody specifically recognizes a cancer cell marker antigen. 7. A method in accordance with claim 6, wherein the antibody is an anti-CD33 antibody or an anti-CD38 antibody. 8. A method in accordance with claim 1, wherein the antibody is administered in a daily dose of about 1 mg to about 10 mg. 9. A method in accordance with claim 1, wherein the antibody is administered for a period of about 1 to about 30 days. |
Details for Patent 5,545,405
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Genzyme Corporation | CAMPATH | alemtuzumab | Injection | 103948 | May 07, 2001 | ⤷ Sign Up | 2013-08-13 |
Genzyme Corporation | LEMTRADA | alemtuzumab | Injection | 103948 | November 14, 2014 | ⤷ Sign Up | 2013-08-13 |
Genzyme Corporation | CAMPATH | alemtuzumab | Injection | 103948 | October 12, 2004 | ⤷ Sign Up | 2013-08-13 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
International Patent Family for US Patent 5,545,405
Country | Patent Number | Estimated Expiration |
---|---|---|
South Africa | 918248 | ⤷ Sign Up |
United States of America | 5545404 | ⤷ Sign Up |
United States of America | 5545403 | ⤷ Sign Up |
>Country | >Patent Number | >Estimated Expiration |
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