Claims for Patent: 5,736,137
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Summary for Patent: 5,736,137
Title: | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
Abstract: | Disclosed herein are therapeutic treatment protocols designed for the treatment of B cell lymphoma. These protocols are based upon therapeutic strategies which include the use of administration of immunologically active mouse/human chimeric anti-CD20 antibodies, radiolabeled anti-CD20 antibodies, and cooperative strategies comprising the use of chimeric anti-CD20 antibodies and radiolabeled anti-CD20 antibodies. |
Inventor(s): | Anderson; Darrell R. (Escondido, CA), Hanna; Nabil (Olivenhain, CA), Leonard; John E. (Encinitas, CA), Newman; Roland A. (San Diego, CA), Reff; Mitchell E. (San Diego, CA), Rastetter; William H. (Rancho Sante Fe, CA) |
Assignee: | Idec Pharmaceuticals Corporation (San Diego, CA) |
Application Number: | 08/149,099 |
Patent Claims: | 1. Immunologically active, chimeric anti-CD20 antibody produced from a transfectoma comprising anti-CD20 in TCAE 8, ATCC deposit number 69119.
2. A pharmaceutical composition comprising the anti-CD20 antibody of claim 1 in a pharmaceutically acceptable carrier. 3. The composition of claim 2, which contains a pharmaceutically acceptable carrier or excipient selected from the group consisting of sterile saline, sterile buffered water, propylene glycol and mixtures thereof. 4. The composition of claim 2, which contains a pharmaceutically acceptable dosage of the antibody which ranges from about 0.001 to about 30 mg/kg of human body weight. 5. The composition of claim 4, which contains a pharmaceutically acceptable dosage of the antibody which ranges from about 0.01 to about 25 mg/kg human body weight. 6. The composition of claim 5, which contains a pharmaceutically acceptable dosage of the antibody which ranges from about 0.4 to about 20.0 mg/kg human body weight. |
Details for Patent 5,736,137
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Acrotech Biopharma Inc. | ZEVALIN | ibritumomab tiuxetan | Injection | 125019 | February 19, 2002 | ⤷ Sign Up | 2015-04-07 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
International Patent Family for US Patent 5,736,137
Country | Patent Number | Estimated Expiration |
---|---|---|
Austria | E139900 | ⤷ Sign Up |
Austria | E196606 | ⤷ Sign Up |
Austria | E421335 | ⤷ Sign Up |
>Country | >Patent Number | >Estimated Expiration |
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