Claims for Patent: 6,680,168

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Summary for Patent: 6,680,168

Title:	Passive immunization against clostridium difficile disease
Abstract:	The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
Inventor(s):	Thomas, Jr.; William D. (Somerville, MA), Giannasca; Paul J. (Newton, MA), Zhang; Zhenxi (Cambridge, MA), Lei; Wende (Cambridge, MA), Monath; Thomas P. (Harvard, MA)
Assignee:	Acambis, Inc. (Cambridge, MA)
Application Number:	09/815,452
Patent Claims:	1. A method of producing human hyperimmune Clostridium difficile toxin-neutralizing immune globulin, said method comprising the steps of: administering a Clostridium difficile toxoid to a human that already has C. difficile neutralizing antibodies; and isolating said Clostridium difficile toxin-neutralizing immune globulin from said human. 2. The method of claim 1, wherein said Clostridium difficile toxoid comprises a toxoid of toxin A and a toxoid of toxin B.

Details for Patent 6,680,168

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	BAYGAM, GAMASTAN S/D	immune globulin (human)	Injection	101134	January 11, 1944	⤷ Subscribe	2017-10-20
Grifols Therapeutics Llc	GAMMAKED, GAMUNEX-C	immune globulin injection (human) 10% caprylate/chromatography purified	Injection	125046	August 27, 2003	⤷ Subscribe	2017-10-20
Octapharma Pharmazeutika Produktionsges.m.b.h.	OCTAGAM	immune globulin intravenous (human)	Injection	125062	May 21, 2004	⤷ Subscribe	2017-10-20
Octapharma Pharmazeutika Produktionsges.m.b.h.	OCTAGAM	immune globulin intravenous (human)	Injection	125062	March 26, 2007	⤷ Subscribe	2017-10-20
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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