Claims for Patent: 7,303,746

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Summary for Patent: 7,303,746

Title:	Methods of treating eye disorders with modified chimeric polypeptides
Abstract:	Modified chimeric polypeptides with improved pharmacokinetics are disclosed useful for treating eye disorders, including age-related macular degeneration and diabetic retinopathy.
Inventor(s):	Wiegand; Stanley J. (Croton on Hudson, NY), Papadopoulos; Nicholas (LaGrangeville, NY), Yancopoulos; George D. (Yorktown Heights, NY)
Assignee:	Regeneron Pharmaceuticals, Inc. (Tarrytown, NY)
Application Number:	10/988,243
Patent Claims:	1. A method of treating retinal neovascularization, comprising administering a fusion polypeptide capable of binding vascular endothelial growth factor (VEGF) to a patient in need thereof, wherein the fusion polypeptide comprises the amino acid sequence of SEQ ID NO:16. 2. The method of claim 1, wherein neovascularization is induced by ischemia. 3. A method of treating, ameliorating, or inhibiting choroidal neovascularization, comprising administering a fusion polypeptide capable of binding vascular endothelial growth factor (VEGE) to a patient in need thereof, wherein the fusion polypeptide comprises the amino acid sequence of SEQ ID NO:16. 4. A method of treating, ameliorating, or inhibiting vascular leak in the retina, comprising administering a fusion polypeptide capable of binding vascular endothelial growth factor (VEGF) to a patient in need thereof, wherein the fusion polypeptide comprises the amino acid sequence of SEQ ID NO:16. 5. A method of treating, ameliorating, or inhibiting retinal edema, comprising administering a fusion polypeptide capable of binding vascular endothelial growth factor (VEGF) to a patient in need thereof, wherein the fusion polypeptide comprises the amino acid sequence of SEQ ID NO:16.

Details for Patent 7,303,746

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Regeneron Pharmaceuticals, Inc.	EYLEA	aflibercept	Injection	125387	November 18, 2011	7,303,746	2039-02-26
Regeneron Pharmaceuticals, Inc.	EYLEA	aflibercept	Injection	125387	August 16, 2018	7,303,746	2039-02-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 7,303,746

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Country	Patent Number	Estimated Expiration
South Africa	200600157	⤷ Subscribe
South Africa	200110068	⤷ Subscribe
Yugoslavia	86901	⤷ Subscribe
World Intellectual Property Organization (WIPO)	2005000895	⤷ Subscribe
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