Claims for Patent: 7,374,758

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Summary for Patent: 7,374,758

Title:	Modified chimeric polypeptides with improved pharmacokinetic properties and methods of using thereof
Abstract:	Modified chimeric polypeptides with improved pharmacokinetics are disclosed. Specifically, modified chimeric Flt1 receptor polypeptides that have been modified in such a way as to improve their pharmacokinetic profile are disclosed. Also disclosed are methods of making and using the modified polypeptides including but not limited to using the modified polypeptides to decrease or inhibit plasma leakage and/or vascular permeability in a mammal.
Inventor(s):	Papadopoulos; Nicholas J. (Lagrangeville, NY), Davis; Samuel (New York, NY), Yancopoulos; George D. (Yorktown Heights, NY)
Assignee:	Regeneron Pharmaceuticals, Inc. (Tarrytown, NY)
Application Number:	11/016,503
Patent Claims:	1. A method of inhibiting vascular endothelial growth factor (VEGF) activity in a mammal, comprising: administering a pharmaceutical composition to the mammal, wherein the pharmaceutical composition comprises (a) a VEGF antagonist, and (b) a pharmaceutically acceptable carrier wherein the VEGF antagonist comprises a dimeric fusion polypeptide comprising two fusion polypeptides, each fusion polypeptide comprising: (i) a VEGF receptor component consisting of an immunoglobulin-like (Ig) domain 2 of a first VEGF receptor human Flt1 and Ig domain 3 of a second VEGF receptor human Flk1 or human Flt4; and (ii) a multimerizing component, wherein VEGF activity is inhibited. 2. The method of claim 1, wherein the mammal is a human. 3. A method of inhibiting tumor growth in a mammal, comprising: administering a pharmaceutical composition to the mammal, wherein the pharmaceutical composition comprises (a) a VEGF antagonist, and (b) a pharmaceutically acceptable carrier wherein the VEGF antagonist comprises a dimeric fusion polypeptide comprising two fusion polypeptides, each fusion polypeptide comprising: (i) a VEGF receptor component consisting of an immunoglobulin-like (Ig) domain 2 of a first VEGF receptor human Flt1 and Ig domain 3 of a second VEGF receptor human Flk1 or human Flt4; and (ii) a multimerizing component, wherein tumor growth is inhibited.

Details for Patent 7,374,758

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Regeneron Pharmaceuticals, Inc.	EYLEA	aflibercept	Injection	125387	November 18, 2011	⤷ Sign Up	2019-06-08
Regeneron Pharmaceuticals, Inc.	EYLEA	aflibercept	Injection	125387	August 16, 2018	⤷ Sign Up	2019-06-08
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 7,374,758

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Country	Patent Number	Estimated Expiration
Argentina	044938	⤷ Sign Up
Austria	E293164	⤷ Sign Up
Austria	E417928	⤷ Sign Up
Austria	E427962	⤷ Sign Up
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