Claims for Patent: 7,547,435
✉ Email this page to a colleague
Summary for Patent: 7,547,435
Title: | Pharmacological vitreolysis |
Abstract: | Methods of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject, comprising contacting a vitreous and/or aqueous humor with a composition comprising a truncated form of plasmin comprising a catalytic domain of plasmin (TPCD) are disclosed. TPCDs include, but are not limited to, miniplasmin, microplasmin and derivatives and variants thereof. The methods of the invention can be used to reduce the viscosity of the vitreous, liquefy the vitreous, induce posterior vitreous detachment, reduce hemorrhagic blood from the eye, clear or reduce materials toxic to the eye, clear or reduce intraocular foreign substances from the eye, increase diffusion of a composition administered to an eye, reduce extraretinal neovascularization and any combinations thereof. The method can be used in the absence of, or as an adjunct to, vitrectomy. |
Inventor(s): | Pakola; Steve (Sleepy Hollow, NY), De Smet; Marc (Amstelveen, NL) |
Assignee: | ThromboGenics NV (Leuven, BE) |
Application Number: | 10/729,475 |
Patent Claims: | 1. A method of liquefying a vitreous and/or inducing posterior vitreous detachment of an eye of a subject, comprising contacting the vitreous and/or an aqueous humor in the
eye of the subject with an effective amount of a composition comprising microplasmin, wherein the method results in liquefying a vitreous and/or inducing posterior vitreous detachment of the eye of a subject.
2. The method of claim 1, wherein said microplasmin is selected from the group consisting of recombinant microplasmin, stabilized microplasmin, and stabilized, recombinant microplasmin. 3. The method of claim 1, wherein the composition is a liquid solution, and wherein the step of contacting the vitreous and/or the aqueous humor with the composition comprises injecting the liquid solution into the vitreous and/or the aqueous humor. 4. The method of claim 1, wherein the subject is a human. 5. The method of claim 1, wherein the method is used for treating a subject having, a vitreoretinal disease or disorder. 6. The method of claim 1, wherein the method is performed in the absence of non-pharmacological vitrectomy. 7. The method of claim 1, wherein the method is performed as an adjunct to vitrectomy. 8. The method of claim 1, wherein an effective amount of microplasmin is in the range of 0.005 mg to 0.2 mg per eye. 9. A method of treating a vitreoretinal disease or disorder, or a complication of a vitreoretinal disease or disorder, of an eye of a subject, comprising contacting a vitreous and/or an aqueous humor in the eye of the subject with an effective amount of a composition comprising microplasmin, wherein the method results in vitreous liquefaction and/or posterior vitreous detachment in the eye of the subject, thereby treating the vitreoretinal disease or disorder, or the complication of the vitreoretinal disease or disorder, of the eye of the subject. 10. The method of claim 9, wherein said microplasmin is selected from the group consisting of recombinant microplasmin, stabilized microplasmin, and stabilized, recombinant microplasmin. 11. The method of claim 9, wherein the composition is a liquid solution, and wherein the step of contacting the vitreous and/or the aqueous humor with the composition comprises injecting the liquid solution into the vitreous and/or the aqueous humor. 12. The method of claim 9, wherein the subject is a human. 13. The method of claim 9, wherein the method is performed in the absence of non-pharmacological vitrectomy. 14. The method of claim 9, wherein the method is performed as an adjunct to vitrectomy. 15. The method of claim 9, wherein an effective amount of microplasmin is in the range of 0.005 mg to 0.2 mg per eye. 16. A method of performing a vitrectomy in a subject, comprising contacting a vitreous and/or aqueous humor of an eye of the subject with an effective amount of a composition comprising microplasmin, prior to or at the same time as the removal of the vitreous. 17. The method of claim 16, wherein said microplasmin is selected from the group consisting of recombinant microplasmin, stabilized microplasmin, and stabilized, recombinant microplasmin. 18. The method of claim 16, wherein the composition is a liquid solution, and wherein the step of contacting the vitreous and/or the aqueous humor with the composition comprises injecting the liquid solution into the vitreous and/or the aqueous humor. 19. The method of claim 16, wherein the subject is a human. 20. The method of claim 16, wherein an effective amount of microplasmin is in the range of 0.005 mg to 0.2 mg per eye. 21. The method of claim 4, wherein the human subject is administered human microplasmin. 22. The method of claim 12, wherein the human subject is administered human microplasmin. 23. The method of claim 19, wherein the human subject is administered human microplasmin. |
Details for Patent 7,547,435
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Thrombogenics Inc. | JETREA | ocriplasmin | Injection | 125422 | February 22, 2017 | 7,547,435 | 2022-12-06 |
Thrombogenics Inc. | JETREA | ocriplasmin | Injection | 125422 | October 17, 2012 | 7,547,435 | 2022-12-06 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
International Patent Family for US Patent 7,547,435
Country | Patent Number | Estimated Expiration |
---|---|---|
South Africa | 200505193 | ⤷ Subscribe |
World Intellectual Property Organization (WIPO) | 2004052228 | ⤷ Subscribe |
United States of America | 9770494 | ⤷ Subscribe |
United States of America | 9186394 | ⤷ Subscribe |
United States of America | 8834869 | ⤷ Subscribe |
United States of America | 8747842 | ⤷ Subscribe |
>Country | >Patent Number | >Estimated Expiration |
Make Better Decisions: Try a trial or see plans & pricing
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.