Claims for Patent: 7,744,886
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Summary for Patent: 7,744,886
| Title: | Methods for interfering with rank signaling |
| Abstract: | Disclosed herein are methods for interfering with RANK signaling by administering blocking antibodies that bind a RANKL polypeptide and inhibit the binding of the RANKL polypeptide to a RANK polypeptide. |
| Inventor(s): | Anderson; Dirk M (Port Townsend, WA) |
| Assignee: | Immunex Corporation (Thousand Oaks, CA) |
| Application Number: | 12/214,914 |
| Patent Claims: | 1. A method of interfering with RANK signaling comprising administering an effective amount of a blocking antibody, wherein the blocking antibody binds to a human RANKL polypeptide as
shown in SEQ ID NO:13 and inhibits the binding of the human RANKL polypeptide to a human RANK polypeptide as shown in SEQ ID NO:6, thereby inhibiting RANK signaling.
2. A method of claim 1, wherein the blocking antibody is a monoclonal antibody. 3. A method of interfering with RANK signaling comprising administering an effective amount of a blocking antibody, wherein the blocking antibody binds to a fragment of a human RANKL polypeptide as shown in SEQ ID NO:13 and inhibits the binding of the human RANKL polypeptide to a human RANK polypeptide as shown in SEQ ID NO:6, thereby inhibiting RANK signaling, wherein the fragment is selected from the group consisting of a) an extracellular domain comprising amino acids 69-317 of SEQ ID NO:13, and b) a receptor binding domain comprising amino acids 162-317 of SEQ ID NO:13. 4. A method of claim 3, wherein the blocking antibody is a monoclonal antibody. |
Details for Patent 7,744,886
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Amgen Inc. | PROLIA | denosumab | Injection | 125320 | June 01, 2010 | 7,744,886 | 2016-12-23 |
| Amgen Inc. | XGEVA | denosumab | Injection | 125320 | November 18, 2010 | 7,744,886 | 2016-12-23 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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International Patent Family for US Patent 7,744,886
| Country | Patent Number | Estimated Expiration |
|---|---|---|
| United States of America | 8715683 | ⤷ Try for Free |
| World Intellectual Property Organization (WIPO) | 9958674 | ⤷ Try for Free |
| World Intellectual Property Organization (WIPO) | 9828426 | ⤷ Try for Free |
| World Intellectual Property Organization (WIPO) | 9828424 | ⤷ Try for Free |
| >Country | >Patent Number | >Estimated Expiration |
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