Claims for Patent: 8,377,690

✉ Email this page to a colleague

Summary for Patent: 8,377,690

Title:	Cells and methods for producing blocking antibodies to human RANKL
Abstract:	Described herein are cell lines and methods for preparing antibodies that bind RANKL, including cell lines that produce blocking antibodies to human RANKL.
Inventor(s):	Anderson; Dirk M (Port Townsend, WA)
Assignee:	Immunex Corporation (Thousand Oaks, CA)
Application Number:	12/802,801
Patent Claims:	1. A cell that produces a blocking antibody, wherein the blocking antibody binds to a human RANKL polypeptide as set forth in SEQ ID NO:13 and inhibits the binding of the human RANKL polypeptide to a human RANK polypeptide as set forth in SEQ ID NO:6. 2. A cell that produces a blocking antibody, wherein the blocking antibody binds to a fragment of a human RANKL polypeptide as set forth in SEQ ID NO:13 and inhibits the binding of the human RANKL polypeptide to a human RANK polypeptide as set forth in SEQ ID NO:6, wherein the fragment is selected from the group consisting of a) an extracellular domain comprising amino acids 69-317 of SEQ ID NO:13, and b) a receptor binding domain comprising amino acids 162-317 of SEQ ID NO:13. 3. A method of producing a blocking antibody, comprising culturing the cell of claim 1 under conditions that permit the production of the blocking antibody. 4. A method of producing a blocking antibody, comprising culturing the cell of claim 2 under conditions that permit the production of the blocking antibody.

Details for Patent 8,377,690

Glossary

Subscribe to access the full database, or Subscribe
Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Amgen Inc.	PROLIA	denosumab	Injection	125320	June 01, 2010	8,377,690	2016-12-23
Amgen Inc.	XGEVA	denosumab	Injection	125320	November 18, 2010	8,377,690	2016-12-23
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 8,377,690

Subscribe to access the full database, or Subscribe
Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	9958674	⤷ Subscribe
World Intellectual Property Organization (WIPO)	9828426	⤷ Subscribe
World Intellectual Property Organization (WIPO)	9828424	⤷ Subscribe
United States of America	8715683	⤷ Subscribe
United States of America	8569456	⤷ Subscribe
United States of America	8333963	⤷ Subscribe
United States of America	8153775	⤷ Subscribe
>Country	>Patent Number	>Estimated Expiration

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.