Claims for Patent: 8,697,193

Summary for Patent: 8,697,193

Title:	Process and apparatus for coating a porous substrate with a coating liquid
Abstract:	An engagement head for engaging a porous substrate includes at least two pin sets, each pin set including a plurality of pins arranged in a plurality of parallel pin rows at a predetermined pin angle, wherein pins of immediately neighboring pin rows are arranged such that pin angles for the pins in a pin row are inversely symmetrical to pin angles for the pins in a neighboring pin row. The pins of a pin row move collectively in the same direction when a pin set is extended, which direction is determined by the pin angle of the pin row, whereby neighboring pin rows move in opposite longitudinal directions from one another when the pin set is extended. The pin sets may be extended and retracted in unison by a single actuation source.
Inventor(s):	Dey; Clifford (Riegelsville, PA), Bohn; Markus (Stuttgart, DE), Schacht; Hans-Steffen (Grosserlach, DE), DeAnglis; Ashley P. (Skillman, NJ), Van Holten; Robert W. (Flemington, NJ), Looney; Dwayne (Flemington, NJ), Llanos; Gerard (Stewartsville, NJ), Brandes; Avner (New York, NY)
Assignee:	Ethicon, Inc. (Somerville, NJ)
Application Number:	13/775,761
Patent Claims:	1. A process for applying a uniform coating of a coating liquid to a surface of a porous substrate, comprising: (a) providing an apparatus having a platform for placement of the porous substrate disposed in a coating vessel, said apparatus also having an engagement head including a sensor array and a plurality of extendable and retractable pins for engaging, retaining, and releasing the substrate evenly into the coating vessel, wherein the plurality of pins are arranged in a plurality of parallel pin rows at a predetermined pin angle, wherein pins of immediately neighboring pin rows are arranged such that pin angles for the pins in a pin row are inversely symmetrical to pin angles for the pins in a neighboring pin row; (b) placing the coating vessel containing the substrate on the platform of the apparatus; (c) extending the pins of the engagement head to engage a surface of the substrate; (d) lifting the engaged substrate out of the coating vessel; (e) verifying that the substrate is evenly engaged using the sensor array; (f) pouring the coating liquid into the empty coating vessel; (g) after the coating liquid has been poured into the coating vessel, lowering the evenly engaged substrate to a release position, and (h) retracting the pins of the engagement head to release the substrate evenly into the coating vessel thereby enabling uniform coating of a surface of the substrate. 2. The process of claim 1, wherein the porous substrate consists of a flexible fabric matrix manufactured from oxidized regenerated cellulose fabric backing into which polyglactin 910 fibers have been embedded. 3. The process of claim 2, wherein the coating liquid consists of a suspension formed by suspending human fibrinogen and human thrombin in a hydrofluoroether solvent.

Details for Patent 8,697,193

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Csl Behring Gmbh	RIASTAP	fibrinogen concentrate (human)	For Injection	125317	January 16, 2009	8,697,193	2028-05-22
Octapharma Pharmazeutika Produktionsges.m.b.h.	FIBRYGA	fibrinogen (human)	For Injection	125612	June 07, 2017	8,697,193	2028-05-22
Instituto Grifols, S.a.	VISTASEAL	fibrin sealant (human)	Frozen	125640	November 01, 2017	8,697,193	2028-05-22