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Last Updated: January 5, 2025

Patent: 10,072,246


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Summary for Patent: 10,072,246
Title:Enhanced generation of cytotoxic T lymphocytes by IL-21 mediated FoxP3 suppression
Abstract: A method of carrying out adoptive immunotherapy by administering a subject an antigen-specific cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount is described. In the method, the CTL preparation is preferably administered as a preparation of an in vitro antigen-stimulated and expanded primate CTL population, the CTL population: (i) depleted of FoxP3+ T lymphocytes prior to antigen stimulation; (ii) antigen-stimulated in vitro in the presence of interleukin-21; or (iii) both depleted of FoxP3+ T lymphocytes prior to antigen stimulation and then antigen-stimulated in vitro in the presence of interleukin-21. Methods of preparing such compositions, and compositions useful for carrying out the adoptive immunotherapy, are also described.
Inventor(s): Yee; Cassian (Seattle, WA), Li; Yongqing (Shoreline, WA)
Assignee: The Fred Hutchinson Cancer Research Center (Seattle, WA)
Application Number:15/188,096
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

Comprehensive Analysis of United States Patent 10,072,246: A Deep Dive into Claims and Patent Landscape

Introduction

Patent analysis is a critical component of intellectual property strategy, involving a systematic review and interpretation of patent documents to understand their implications and value. This article will provide a comprehensive and critical analysis of the claims and the patent landscape for United States Patent 10,072,246, highlighting key aspects such as inventorship, prior art, freedom to operate, competitive intelligence, and strategic insights.

Understanding the Patent

Patent Details

United States Patent 10,072,246 is a utility patent that grants exclusive rights to the inventors for their specific invention. To begin the analysis, it is essential to review the patent's title, abstract, inventors, assignees, publication date, citations, and claims. This information provides a foundational understanding of the patent's scope and significance.

Inventorship Determination

Conception and Reduction to Practice

Inventorship in U.S. patent law is determined primarily by the conception step, which involves the formation of a definite and permanent idea of the complete and operative invention[1]. For a person to be considered an inventor, they must have conceived the subject matter of at least one claim of the patent. This determination is crucial as errors in inventorship can lead to the patent being invalid and unenforceable if there was deceptive intent.

Collaborative Efforts

In cases where multiple individuals collaborate to produce the invention, each contributor who conceived part of the invention should be listed as an inventor. However, individuals who only reduce the invention to practice using ordinary skill in the art are not considered inventors[1].

Prior Art Search

Importance of Prior Art

Conducting a thorough prior art search is essential to determine the novelty and non-obviousness of the invention claimed in the patent. This involves a systematic review of global patent publications and non-patent literature to identify any existing technologies or innovations that may affect the validity or patentability of the invention[2][3].

Impact on Patent Validity

Prior art searches help in assessing whether the claims of the patent are novel and non-obvious. If prior art discloses similar inventions, it may necessitate revising the claims to improve patentability. This step is critical in ensuring that the patent remains enforceable and valid.

Freedom to Operate (FTO) Analysis

Avoiding Infringement

FTO analysis is vital to ensure that the product or process described in the patent does not infringe on existing patents. This involves assessing whether the invention can be manufactured, used, or sold without violating someone else's intellectual property rights. Conducting FTO analysis helps businesses avoid costly patent infringement litigation[2].

Competitive Intelligence

Monitoring Competitors

Analyzing the patent portfolios of competitors provides valuable insights into their technological advancements and strategic directions. By tracking competitors' patent filings, businesses can assess their strengths and weaknesses, identify potential threats, and develop strategies to protect and expand their market share[2].

Patent Valuation and Strategic Insights

Economic Value

Patent valuation involves evaluating the potential economic value of the patent, considering factors such as market size, licensing opportunities, and litigation risks. This analysis helps in determining the strategic importance of the patent and how it can be leveraged for business growth[2].

Strategic Decision-Making

Patent analysis aids in strategic decision-making by identifying areas where investments in new technologies are warranted, forming partnerships, or licensing existing patents. It also helps in identifying white spaces for innovation and assessing the competitive landscape[2].

Citation Analysis and Patent Family

Understanding Patent Impact

Citation analysis examines how a patent relates to prior and subsequent innovations, gauging its importance within a technological field. Patent family analysis determines the geographical coverage of the patent and whether it has been filed in multiple countries, providing insights into its global reach[2].

Technology Classification and Trends

Categorization and Evolution

Assigning appropriate technology classifications or codes to patents helps in categorizing them by technology area, making it easier to analyze and compare. Plotting patent filing trends over time helps in understanding the evolution of technology in the field and identifying peaks and valleys in innovation activity[2].

Risk Mitigation

Identifying Vulnerabilities

Conducting a thorough patent analysis helps in identifying potential risks associated with the intellectual property strategy. This includes identifying patents that may be vulnerable to challenges and assessing the validity and enforceability of the patents[2].

Legal and Regulatory Compliance

Ensuring Compliance

Patent analysis is crucial for ensuring legal and regulatory compliance. It involves verifying that all documents, including those prepared with the assistance of AI tools, do not introduce inaccurate statements or omit material information that is critical to patentability[5].

Case Study: United States Patent 10,072,246

Claims Analysis

To analyze the claims of United States Patent 10,072,246, one must carefully review each claim to understand the scope and meaning of the subject matter. This involves identifying the key features of the invention and determining how they are protected by the patent.

Prior Art Search Results

A prior art search for this patent would involve identifying any existing technologies or innovations that may affect its validity. If similar inventions are found, it may be necessary to revise the claims to ensure the patent remains valid.

Competitive Landscape

Analyzing the competitive landscape involves reviewing the patent portfolios of competitors in the same technological field. This helps in understanding the strengths and weaknesses of competitors and identifying potential threats or opportunities.

Strategic Insights

Based on the analysis, strategic insights can be drawn to guide business decisions. This may include identifying areas for innovation, assessing the competitive landscape, and making recommendations for R&D or business strategy.

Key Takeaways

  • Inventorship Determination: Accurate identification of inventors is crucial to ensure the patent's validity and enforceability.
  • Prior Art Search: Conducting thorough prior art searches is essential to ensure the novelty and non-obviousness of the invention.
  • Freedom to Operate: FTO analysis is vital to avoid patent infringement and ensure the right to manufacture, use, or sell the invention.
  • Competitive Intelligence: Analyzing competitors' patent portfolios helps in assessing their strengths and weaknesses.
  • Patent Valuation: Evaluating the economic value of the patent aids in strategic decision-making.
  • Risk Mitigation: Identifying potential risks associated with the intellectual property strategy is crucial for maintaining patent validity.

FAQs

Q: What is the primary factor in determining inventorship in U.S. patent law?

A: The primary factor is the conception step, which involves the formation of a definite and permanent idea of the complete and operative invention[1].

Q: Why is prior art search important in patent analysis?

A: Prior art search is crucial to determine the novelty and non-obviousness of the invention, ensuring that the patent claims are valid and enforceable[2][3].

Q: What is Freedom to Operate (FTO) analysis, and why is it important?

A: FTO analysis assesses whether a product or process infringes on existing patents, helping businesses avoid costly patent infringement litigation[2].

Q: How does patent analysis aid in strategic decision-making?

A: Patent analysis helps in identifying areas for innovation, assessing the competitive landscape, and making recommendations for R&D or business strategy[2].

Q: Can AI tools contribute to the drafting of patent documents, and what are the implications?

A: AI tools can assist in drafting patent documents, but practitioners must verify the accuracy of the content to ensure it complies with patent law and does not introduce inaccurate statements[5].

Sources

  1. Determination of proper inventorship for US Patent Applications - Oregon State University
  2. Patent Analysis - Evalueserve
  3. Patent Search Services - Clarivate
  4. Equity in Innovation: Trends in U.S. Patenting and Inventor Diversity - Congressional Research Service
  5. U.S. Patent Office Issues Additional Guidance on Use of AI Tools - Buchanan Ingersoll & Rooney PC

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Details for Patent 10,072,246

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Eisai, Incorporated ONTAK denileukin diftitox Injection 103767 February 05, 1999 10,072,246 2027-10-03
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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