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Last Updated: March 14, 2025

Patent: 10,086,010


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Summary for Patent: 10,086,010
Title:Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells
Abstract: In one embodiment, the invention provides a method of treating a subject who suffers from a neoplasm (including a cancer such as a radiotherapeutic-resistant cancer) by administering to the subject a therapeutically effective amount of (a) 5-formyl-2\'-deoxyuridine (fdU or foUdR) or a 5-formyl-2\'-deoxyuridine derivative, optionally in combination with 5-hydroxy-2\'-deoxyuridine (hUdR); and (b) at least one composition selected from the group consisting of either 5-fluorouracil (5-FU), a 5-FU prodrug (e.g. 5-fluoro-2\'-deoxyuridine (FdU)) or 5-FU metabolite. In a preferred embodiment, a subject who suffers from colorectal cancer (CRC) or metastatic colorectal cancer (mCRC) is treated with a therapeutically-effective amount of fdU and either 5-FU or the 5-FU prodrug 5-fluoro-2\'-deoxyuridine (FdU). Related pharmaceutical compositions are also provided.
Inventor(s): Matsumoto; Yoshihiro (Kasugai, JP), Tomkinson; Alan Edward (Albuquerque, NM), Ide; Hiroshi (Higashi-Hiroshima, JP)
Assignee: STC.UNM (Albuquerque, NM)
Application Number:15/126,777
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

Transforming Innovations: A Comprehensive Analysis of the Patent Landscape for US Patents

Introduction

In the dynamic world of innovation, patents play a crucial role in protecting intellectual property and driving technological advancement. This article delves into the complexities of the patent landscape, particularly focusing on the implications and strategies surrounding US patents, using the context of Chinese exporters and general patent trends.

The Significance of US Patents for Chinese Exporters

Chinese exporters filing for US patents are often larger, more productive, and technologically advanced compared to their counterparts who do not seek such protection. A US patent grant can significantly enhance a firm's credibility and quality signals globally, which can be pivotal in foreign markets[1].

Monopoly Power and Market Protection

A US patent grants the holder exclusive rights to use the underlying technology or invention for a specific period. This monopoly power is particularly significant in the US market, where the patent protection is legally recognized. However, this effect is generally confined to the exports of products directly covered by the patent and sold to the US market[1].

Global Signals of Quality and Credibility

Beyond market protection, US patents serve as valuable global signals of quality and credibility. This can lead to increased trust from consumers and partners, thereby enhancing the firm's export outcomes. The quasi-random assignment of patent applications to examiners helps in disentangling the causal impact of a US patent grant on firm exports, highlighting the positive effects on firms that successfully obtain patents[1].

The Increasing Complexity of Patent Applications

The number of patent applications filed at the United States Patent & Trademark Office (USPTO) has seen a significant increase over the years. From approximately 100,000 applications per year between 1963 and 1983, the number jumped to 326,508 in 2001 alone. This trend is driven by technology innovation and facilitated by advancements in technology such as word processing and remote electronic database searching[2].

The Rise in Patent Claims

Along with the increase in patent applications, the number of claims filed with each application has also risen. Some patent applications now include several hundred claims, with the maximum identified being 7,976 claims. This increase is partly due to legal precedents such as the Festo Corporation v. Shoketsu Kinzoku Kogyo Kabushiki Co. Ltd. case, which interpreted that narrowing amendments to claims elements during patent prosecution can limit the scope of patent claims[2].

Challenges in Patent Claims Analysis

Given the vast number of patent applications and claims, there is a growing need for automated methods to analyze and manage patent claims. The current system is overwhelmed, making it difficult for users to review and make judgments related to patent claims. Automated systems and methods are being developed to reduce the amount of information users need to review, facilitating more efficient patent grant and application processes[2].

Asserting Patents in the US: Legal and Strategic Considerations

Chinese companies asserting patents in the US must navigate a complex legal landscape. Recent changes in US law have tilted in favor of patent owners, particularly in terms of willfulness and enhanced damages.

Willfulness and Enhanced Damages

The Supreme Court has lowered the evidentiary standard for proving willful infringement from "clear and convincing" to "preponderance," making it easier for patent owners to seek enhanced damages and recovery of attorneys’ fees[3].

Inter Partes Review (IPR)

IPR proceedings before the USPTO's Patent Trial and Appeal Board (PTAB) have become a common defense mechanism. While initially criticized as a "patent death squad," the PTAB has begun to tilt back towards parity, with fewer claims being found unpatentable over time. IPR proceedings can strengthen patents and provide tactical advantages in litigation, such as IPR estoppel, which limits an accused infringer's grounds for asserting invalidity[3].

Requirements for Patent Eligibility

For a patent to be granted, the invention must meet specific eligibility criteria under 35 U.S.C. 101.

Double Patenting Prohibited

No more than one patent can be issued for the same invention to the same inventor or where there is a common inventor or applicant/assignee. This prevents duplicate patents on identical subject matter[4].

Subject Matter Eligibility

The claimed invention must fall within one of the four statutory categories: processes, machines, manufactures, or compositions of matter. It must also be useful, with a specific, substantial, and credible utility. Rejections for lack of utility are appropriate if the invention's utility is not apparent or if the asserted utility is not credible[4].

Strategic Implications for Patent Holders

Patent holders must strategically manage their patents to maximize their benefits.

Leveraging IPR Proceedings

IPR proceedings can be used not only to contest the validity of patents but also to strengthen them. A favorable outcome in an IPR can make it more difficult for challengers to invalidate the patent in subsequent proceedings[3].

Managing Patent Claims

Given the increasing complexity of patent claims, automated systems can help in analyzing and managing these claims efficiently. This is crucial for both patent applicants and holders to ensure their intellectual property is well-protected and communicated effectively[2].

Case Study: The Impact of US Patents on Chinese Exporters

A study on Chinese exporters filing for US patents highlights the transformative effects of such patents. Successful patent applicants are generally more successful in foreign markets due to the enhanced credibility and quality signals associated with US patents. The quasi-random assignment of patent applications to examiners helps in isolating the causal impact of the patent grant, showing that successful applicants tend to be more productive and technologically advanced[1].

Key Takeaways

  • Enhanced Credibility: US patents serve as global signals of quality and credibility, enhancing a firm's export outcomes.
  • Monopoly Power: US patents grant exclusive rights, particularly significant in the US market.
  • Complexity in Patent Applications: The increasing number of patent applications and claims necessitates automated analysis systems.
  • Legal Considerations: Recent US law changes favor patent owners, and IPR proceedings can strategically strengthen patents.
  • Eligibility Criteria: Patents must meet specific eligibility criteria, including subject matter eligibility and utility.

FAQs

Q: How do US patents impact Chinese exporters?

US patents significantly enhance the credibility and quality signals of Chinese exporters, making them more successful in foreign markets.

Q: What is the role of IPR proceedings in patent litigation?

IPR proceedings can contest the validity of patents and strategically strengthen them by limiting an accused infringer's grounds for asserting invalidity.

Q: Why is there an increase in the number of patent claims?

The increase is partly due to legal precedents and the growing complexity of technological innovations, which require more detailed claims to protect intellectual property.

Q: What are the eligibility criteria for a patent under 35 U.S.C. 101?

A patent must fall within one of the four statutory categories (processes, machines, manufactures, or compositions of matter) and must be useful with a specific, substantial, and credible utility.

Q: How do automated systems help in patent claims analysis?

Automated systems reduce the amount of information users need to review, facilitating more efficient patent grant and application processes by analyzing and managing patent claims effectively.

Sources

  1. The transformative effects of US patents for Chinese exporters - VoxDev
  2. US20110138338A1 - Patent Claims Analysis System and Method - Google Patents
  3. Chinese Companies Asserting Patents in the U.S. - Sills Cummis
  4. 2104-Requirements of 35 U.S.C. 101 - USPTO

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Details for Patent 10,086,010

ApplicantTradenameBiologic IngredientDosage FormBLAApproval DatePatent No.Expiredate
Eli Lilly And Company ERBITUX cetuximab Injection 125084 February 12, 2004 ⤷  Try for Free 2034-03-18
Eli Lilly And Company ERBITUX cetuximab Injection 125084 March 28, 2007 ⤷  Try for Free 2034-03-18
Genentech, Inc. AVASTIN bevacizumab Injection 125085 February 26, 2004 ⤷  Try for Free 2034-03-18
>Applicant>Tradename>Biologic Ingredient>Dosage Form>BLA>Approval Date>Patent No.>Expiredate
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