Patent: 10,125,195

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Summary for Patent: 10,125,195

Scope and claims summary:

Title:	Stable anti-IFNAR1 formulation
Abstract:	The present invention relates to a stable, low viscosity antibody formulation, wherein the formulation comprises a high concentration of anti-INFAR1 antibody. In some embodiments, the invention relates in general to a stable antibody formulation comprising about 100 mg/mL to about 200 mg/mL of an antibody or fragment thereof that specifically binds human interferon alpha 1 (INFAR1); about 20 mM to about 80 mM of a lysine or a salt thereof; about 0.02% to about 0.06% of a surfactant; an uncharged excipient; and a formulation buffer. In some embodiments, the invention is directed to a container, dosage form and/or kit. In some embodiments, the invention is directed to a method of making and using the stable antibody formulation.
Inventor(s):	Depaz Roberto, DeJesus Natalie, Bee Jared
Assignee:	AstraZeneca AB
Application Number:	US15240224
Patent Claims:	see list of patent claims

Details for Patent 10,125,195

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Astrazeneca Ab	SAPHNELO	anifrolumab-fnia	Injection	761123	July 30, 2021	⤷ Subscribe	2036-08-18
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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