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Last Updated: December 23, 2024

Patent: 10,195,175


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Summary for Patent: 10,195,175
Title:Synergistic effect of anti-Trop-2 antibody-drug conjugate in combination therapy for triple-negative breast cancer when used with microtubule inhibitors or PARP inhibitors
Abstract: The present invention relates to combination therapy with ADCs against a tumor-associated antigen, such as Trop-2, and drugs, such as microtubule inhibitors and/or PARP inhibitors. Where ADCs are used, they preferably incorporate SN-38 or another drug that induces DNA strand breaks. Preferably, the combination of ADC and PARPi or microtubule inhibitor exhibits synergistic effects against the cancer. The combination therapy can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy.
Inventor(s): Goldenberg; David M. (Mendham, NJ), Cardillo; Thomas M. (Cedar Knolls, NJ)
Assignee: Immunomedics, Inc. (Morris Plains, NJ)
Application Number:15/481,090
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

The Value and Landscape of United States Patent 10,195,175: A Comprehensive Analysis

Introduction

Patents are a cornerstone of innovation, providing exclusive rights to inventors and companies, and thereby incentivizing the development of new technologies. This article delves into the specifics of United States Patent 10,195,175, analyzing its claims, the broader patent landscape, and the methodologies used to value such intellectual property.

Understanding the Patent

To begin with, it is crucial to understand the subject matter of the patent in question. While the specific details of U.S. Patent 10,195,175 are not provided here, a typical patent includes claims that define the scope of the invention, a detailed description of the invention, and background information.

Claims Analysis

The claims section of a patent is the most critical part as it defines the legal boundaries of the invention. Here, each claim must be clear, concise, and supported by the description provided in the patent. The claims can be divided into independent and dependent claims, with independent claims standing alone and dependent claims referring back to one or more of the independent claims.

Patent Valuation Methods

Valuing a patent involves several methodologies, each with its own strengths and weaknesses.

Cost Approach

The cost approach values a patent based on the cost to develop or replace it. This method is less commonly used for patents because it does not account for the future economic benefits the patent may generate[1].

Income Approach

The income approach is more relevant as it estimates the present value of the future economic benefits derived from the patent. This includes royalties, licensing fees, and cost savings. It is a forward-looking method that considers the patent's lifetime and the expected cash flows it will generate[1].

Market Approach

The market approach looks at comparable sales of similar patents to determine the value. This method is particularly useful when there are recent sales data available for similar patents. For instance, the sale of Novell's 882 patents for $450 million in 2010, or the $4.5 billion paid for Nortel's 6,000 patent documents, provide benchmarks for valuing large patent portfolios[1].

The Broader Patent Landscape

Global Patent Filings

The global patent landscape is dynamic and highly competitive. In 2023, China led the world with 1,769,299 patent applications, followed by the United States with 418,262 applications. Japan and the European Patent Office also showed significant activity, highlighting the global emphasis on innovation and intellectual property protection[3].

USPTO Statistics

In the United States, the USPTO granted 348,399 patents in 2023, with 313,219 being utility patents and 35,180 being design patents. This reflects a strong innovation climate, particularly in sectors such as electric digital data processing, transmission of digital information, and wireless communication networks[3].

Legal and Regulatory Framework

Patent Eligibility

The legal framework governing patents, especially in the U.S., is complex and evolving. The Supreme Court's decisions, such as in Diamond v. Diehr and Mayo Collaborative Servs. v. Prometheus Laboratories, Inc., have significantly shaped the eligibility criteria for patents under 35 U.S.C. §101. These decisions emphasize the distinction between patent-eligible subject matter and ineligible concepts, such as natural laws and abstract ideas[2].

Impact of Supreme Court Precedents

The Diehr case, for example, established that the use of a well-known mathematical equation in conjunction with other steps could be patent-eligible, as long as the overall process was not merely an abstract idea. In contrast, Mayo expanded the "inventive concept" test, requiring that claims must include an element or combination of elements that amount to significantly more than the ineligible concept itself[2].

Economic and Strategic Value

Market Transactions

The economic value of patents is often realized through market transactions. For instance, Google's acquisition of Motorola Mobility's patents for $12.5 billion in 2011, or the consortium led by Apple and Microsoft paying $4.5 billion for Nortel's patents, demonstrate the high stakes involved in patent acquisitions[1].

Licensing and Royalties

Patents can generate significant revenue through licensing and royalties. Companies often license their patents to other firms, creating a stream of income that can be substantial. The income approach to valuation takes these future benefits into account, making it a critical method for assessing the value of a patent[1].

Industry Trends and Innovations

Technological Sectors

The patent landscape is heavily influenced by technological trends. In 2023, sectors such as electric digital data processing, transmission of digital information, and wireless communication networks saw a high number of patent grants. These trends indicate the rapid advancement and innovation in digital technologies and telecommunications[3].

Medical and Healthcare Innovations

The field of diagnosis, surgery, and identification also saw significant patent activity, with 15,007 patents granted in 2023. This reflects the continuous innovation in medical technologies and healthcare, driven by the need for better treatments and diagnostic tools[3].

Challenges and Opportunities

Patent Litigation

Patent litigation is a significant challenge in the patent landscape. The complexity and cost of patent disputes can be daunting, and the outcomes are often uncertain. However, successful litigation can also protect the value of a patent and deter infringement[2].

International Protection

The global nature of innovation means that international protection of intellectual property is crucial. The World Intellectual Property Organization (WIPO) and regional patent offices like the European Patent Office play vital roles in facilitating international patent applications and grants[3].

Key Takeaways

  • Valuation Methods: Patents can be valued using the cost, income, and market approaches, each with its own strengths and weaknesses.
  • Global Trends: The global patent landscape is highly competitive, with China, the U.S., Japan, and Europe being key players.
  • Legal Framework: Supreme Court decisions significantly influence patent eligibility criteria, emphasizing the distinction between eligible and ineligible subject matter.
  • Economic Value: Patents can generate substantial revenue through licensing, royalties, and market transactions.
  • Industry Trends: Technological sectors such as digital data processing and medical technologies are driving innovation and patent activity.

FAQs

What are the primary methods for valuing a patent?

The primary methods for valuing a patent include the cost approach, income approach, and market approach. Each method has its own application and relevance depending on the context and available data[1].

How do Supreme Court decisions impact patent eligibility?

Supreme Court decisions, such as Diamond v. Diehr and Mayo Collaborative Servs. v. Prometheus Laboratories, Inc., have established key precedents that shape the eligibility criteria for patents under 35 U.S.C. §101. These decisions clarify what constitutes patent-eligible subject matter and what does not[2].

What are the most active sectors in terms of patent filings?

In 2023, the most active sectors included electric digital data processing, transmission of digital information, wireless communication networks, and medical technologies such as diagnosis, surgery, and identification[3].

How do companies realize the economic value of patents?

Companies can realize the economic value of patents through licensing agreements, royalties, and market transactions such as buying or selling patent portfolios[1].

Why is international protection of intellectual property important?

International protection is crucial because it allows inventors and companies to safeguard their inventions in multiple jurisdictions, thereby protecting their intellectual property on a global scale[3].

Sources

  1. The Value of a Patent - Perpetual Motion Patents
  2. Flaws in the Supreme Court's §101 Precedent and Ways to Correct - IP Watchdog
  3. USPTO 2023 Patent Statistics: Unveiling Innovation Trends - TT Consultants

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Details for Patent 10,195,175

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Recordati Rare Diseases, Inc. ELSPAR asparaginase For Injection 101063 January 10, 1978 ⤷  Subscribe 2035-06-25
Bristol-myers Squibb Company YERVOY ipilimumab Injection 125377 March 25, 2011 ⤷  Subscribe 2035-06-25
Merck Sharp & Dohme Llc KEYTRUDA pembrolizumab For Injection 125514 September 04, 2014 ⤷  Subscribe 2035-06-25
Merck Sharp & Dohme Llc KEYTRUDA pembrolizumab Injection 125514 January 15, 2015 ⤷  Subscribe 2035-06-25
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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