Patent: 10,472,424

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Summary for Patent: 10,472,424

Scope and claims summary:

Title:	Treatment with anti-PCSK9 antibodies
Abstract:	The present invention relates to therapeutic dosing regimens utilizing a dose reduction strategy for treating disorders characterized by marked elevations of low density protein cholesterol (LDL-C) in the plasma of a patient. The subject therapeutic dosing regimens involve delivering as a single administration or plurality of administrations of an anti-proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist antibody as an initial dose of at least about 100 mg, and delivering as a single administration or plurality of administrations at a subsequent dose in an amount that is about the same as the initial dose, or at least half the initial dose after the patient has a LDL-C level at or below about 25, 20, 15 or 10 mg/dL, preferably at or below 10 mg/dL.
Inventor(s):	Cropp; Anne Barbara (Madison, CT), Kim; Albert (Newton, MA), Plowchalk; David Raymond (Waterford, CT), Sweeney; Kevin Richard (East Lyme, CT), Wang; Ellen Qiao (Brooklyn, NY)
Assignee:	Pfizer Inc. (New York, NY)
Application Number:	15/510,600
Patent Claims:	see list of patent claims

Details for Patent 10,472,424

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Amgen Inc.	REPATHA	evolocumab	Injection	125522	August 27, 2015	⤷ Subscribe	2034-09-23
Amgen Inc.	REPATHA	evolocumab	Injection	125522	July 08, 2016	⤷ Subscribe	2034-09-23
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>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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