Patent: 4,530,787

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Summary for Patent: 4,530,787

Title:	Controlled oxidation of microbially produced cysteine-containing proteins
Abstract:	Method of oxidizing reduced cysteine-containing microbially produced synthetic proteins, such as synthetic IFN-.beta. or synthetic IL-2, in a controlled manner so that the synthetic proteins have the same disulfide bridging as their native counterparts. The oxidation employs o-iodosobenzoate as oxidizing agent and is carried out in an aqueous medium at a pH at least about one-half pH unit less than the pK.sub.a of the cysteines to be oxidized, a synthetic protein concentration of less than about 5 mg/ml, and an oxidizing agent:protein mol ratio that is at least stoichiometric, provided that the oxidizing agent is in excess in the terminal portion of the reaction.
Inventor(s):	Shaked; Ze\'ev (Berkeley, CA), Wolfe; Sidney N. (Richmond, CA)
Assignee:	Cetus Corporation (Emeryville, CA)
Application Number:	06/661,902
Patent Claims:	see list of patent claims

Details for Patent 4,530,787

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bayer Healthcare Pharmaceuticals Inc.	BETASERON	interferon beta-1b	For Injection	103471	July 23, 1993	⤷ Sign Up	2004-03-28
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 4,530,787

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Country	Patent Number	Estimated Expiration
Austria	108186	⤷ Sign Up
Austria	196769	⤷ Sign Up
Canada	1233172	⤷ Sign Up
Germany	156354	⤷ Sign Up
Germany	3587873	⤷ Sign Up
Germany	3588226	⤷ Sign Up
European Patent Office	0156354	⤷ Sign Up
>Country	>Patent Number	>Estimated Expiration

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