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Last Updated: April 26, 2025

Patent: 6,921,659


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Summary for Patent: 6,921,659
Title:Protease-deficient cells
Abstract:A gram-negative bacterial cell is described that is deficient in a chromosomal gene present in a wild-type such cell which gene shares at least 80% sequence identity with the native sequence of the yfcK gene and encodes an aminopeptidase. Alternatively, a gram-negative bacterial cell is deficient in a chromosomal gene present in a wild-type such cell which gene encodes an aminopeptidase that shares at least 80% sequence identity with the native sequence of aminopeptidase b2324. Either of these types of cells, when comprising a nucleic acid encoding a heterologous polypeptide, produces an N-terminal unclipped polypeptide when it is cultured and the polypeptide recovered, with virtually no N-terminal clipped polypeptide produced as an impurity. Conversely, a method is provided for cleaving an N-terminal amino acid from a polypeptide comprising contacting the polypeptide with an aminopeptidase sharing at least 80% sequence identity with the native sequence of aminopeptidase b2324.
Inventor(s):John C. Joly
Assignee:Genentech Inc
Application Number:US10/243,789
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

Analyzing the Claims and Patent Landscape of United States Patent 6,921,659

Introduction

United States Patent 6,921,659, though not specifically detailed in the provided sources, can be analyzed using general principles of patent analysis. This article will guide you through a comprehensive and critical analysis of the claims and the broader patent landscape, using relevant methodologies and tools.

Understanding the Patent

To begin, it is crucial to understand the specifics of the patent in question, including its title, abstract, claims, and the background of the invention.

Title and Abstract

The title and abstract provide a preliminary overview of the invention. These sections are critical for identifying the core concept and the problem the invention aims to solve.

Claims

The claims section is the most important part of a patent, as it defines the scope of the invention and what is protected by the patent. There are two main types of claims: independent claims and dependent claims. Independent claims stand alone and define the invention, while dependent claims refer back to and further limit the independent claims[4].

Prior Art Search

Conducting a thorough prior art search is essential to determine the novelty and non-obviousness of the invention.

Global Patent Databases

Utilize global patent databases such as the USPTO's Patent Public Search, the European Patent Office's esp@cenet, and the World Intellectual Property Organization's PATENTSCOPE to search for existing patents and published patent applications that may be relevant to the invention[4].

Patentability Search

Perform a patentability search to identify references that disclose the same or similar inventions. This involves a thorough search of global patent publications and non-patent literature to determine if the claims should be revised[3].

Claim Analysis

Claim Construction

Analyze each claim to understand its scope and limitations. This involves identifying the key elements of the claim and determining how they interact with each other.

Claim Validity

Assess the validity of the claims by comparing them against prior art. This helps in determining whether the invention is novel and non-obvious over the existing state of the art[5].

Patent Landscape Analysis

Market Assessment

Analyze the patent landscape to understand the competitive environment. This includes identifying key players, their patent portfolios, and areas of innovation. This information is crucial for strategic decision-making and market entry strategies[5].

Technology Classification

Classify the patent within its technological field. This helps in understanding how the patent relates to other innovations in the same field and can be done using classification systems like the International Patent Classification (IPC)[5].

Citation Analysis

Examine patent citations to understand the impact and relevance of the patent within its field. Citation analysis can help gauge the importance of the patent and its position within the broader technological landscape[5].

Patent Family Analysis

Analyze the patent family to determine the geographical coverage of the patent. This involves identifying whether the patent has been filed in multiple countries and understanding the status of these applications[5].

Risk Mitigation and Legal Compliance

Patent (In)Validity Search

Conduct a comprehensive global prior art search to defend against patent infringement assertions or to assess the validity of the patent before enforcement. This helps in identifying potential risks associated with the intellectual property strategy[3].

Disclosure and Compliance

Ensure that all material information, including the use of AI tools if applicable, is disclosed to the patent office. This is crucial for maintaining the integrity of the patent application and avoiding potential legal issues[2].

Strategic Planning and R&D

Identifying White Spaces

Analyze patents in the field to identify areas with fewer patents, indicating potential opportunities for innovation. This helps in refining R&D strategies and making informed decisions about where to invest in new technologies[5].

Licensing and Partnerships

Use patent analysis to identify areas where licensing existing patents or forming partnerships could be beneficial. This aids in achieving business goals and expanding the company's technological capabilities[5].

Valuation of Intellectual Property

Financial Valuation

Determine the financial value of the patent, which is essential for licensing, mergers and acquisitions, and negotiations with potential investors or partners. Effective patent analysis helps in assessing the value of the patent portfolio[5].

Technology Transfer

Commercial Potential

Identify technologies with commercial potential through patent analysis. This facilitates the transfer of knowledge and technologies from research settings to the marketplace, aiding in the commercialization of research[5].

Key Takeaways

  • Thorough Prior Art Search: Essential for determining the novelty and non-obviousness of the invention.
  • Claim Analysis: Critical for understanding the scope and limitations of the patent.
  • Patent Landscape Analysis: Helps in understanding the competitive environment and making strategic decisions.
  • Risk Mitigation: Important for identifying and mitigating potential risks associated with the intellectual property strategy.
  • Strategic Planning: Aids in refining R&D strategies and making informed business decisions.
  • Valuation and Technology Transfer: Crucial for assessing the financial value and commercial potential of the patent.

FAQs

Q1: What is the importance of prior art search in patent analysis? Prior art search is crucial for determining the novelty and non-obviousness of an invention, ensuring that the patent application is valid and enforceable.

Q2: How do you analyze the claims of a patent? Claim analysis involves understanding the scope and limitations of each claim, identifying key elements, and assessing the validity of the claims against prior art.

Q3: What is patent landscape analysis, and why is it important? Patent landscape analysis involves understanding the competitive environment by identifying key players, their patent portfolios, and areas of innovation. This is important for strategic decision-making and market entry strategies.

Q4: How does citation analysis help in patent evaluation? Citation analysis helps in understanding the impact and relevance of a patent within its field by examining how often the patent is cited by other patents, indicating its importance and position within the technological landscape.

Q5: Why is it important to disclose the use of AI tools in patent applications? Disclosing the use of AI tools is important to ensure that the patent application is transparent and compliant with patent office regulations, avoiding potential legal issues related to inventorship and materiality.

Sources

  1. Canadian Patents Database - Patent 3113432 Summary
  2. Buchanan Ingersoll & Rooney PC - U.S. Patent Office Issues Additional Guidance on Use of AI Tools
  3. Clarivate - Patent Search Services
  4. USPTO - Search for patents
  5. Evalueserve - Patent Analysis

More… ↓

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Details for Patent 6,921,659

ApplicantTradenameBiologic IngredientDosage FormBLAApproval DatePatent No.Expiredate
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 June 30, 2006 6,921,659 2021-09-13
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 August 10, 2012 6,921,659 2021-09-13
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 October 13, 2016 6,921,659 2021-09-13
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 March 20, 2018 6,921,659 2021-09-13
>Applicant>Tradename>Biologic Ingredient>Dosage Form>BLA>Approval Date>Patent No.>Expiredate
Showing 1 to 4 of 4 entries

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