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Last Updated: December 25, 2024

Patent: 6,143,524


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Summary for Patent: 6,143,524
Title: Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules
Abstract:Provided is a fusion molecule comprising a DNA sequence encoding a thioredoxin-like protein fused to a DNA sequence encoding a second peptide or protein. The peptide or protein may be fused to the amino terminus of the thioredoxin-like molecule, the carboxyl terminus of the thioredoxin-like molecule, or within the thioredoxin-like molecule, for example at the active-site loop of the molecule. The fusion molecule may be modified to introduce one or more metal-binding/chelating amino-acid residues to aid in purification. Expression of this fusion molecule under the control of a regulatory sequence capable of directing its expression in a desired host cell, produces high levels of stable and soluble fusion protein. The fusion protein, located in the bacterial cytoplasm, may be selectively released from the cell by osmotic shock or freeze/thaw procedures. It may be optionally cleaved to liberate the soluble, correctly folded heterologous protein from the thioredoxin-like portion.
Inventor(s): McCoy; John (Reading, MA), DiBlasio-Smith; Elizabeth (Tyngsboro, MA), Grant; Kathleen (Salem, MA), LaVallie; Edward R. (Tewksbury, MA)
Assignee: Genetics Institute, Inc. (Cambridge, MA)
Application Number:08/810,436
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

Comprehensive Analysis of the Claims and Patent Landscape for United States Patent 6,143,524

Introduction

United States Patent 6,143,524, though not specifically detailed in the provided sources, can be analyzed using general principles of patent landscape analysis, claim scrutiny, and the broader context of patent law and practice. This article will guide you through a critical analysis of the claims and the patent landscape, using relevant examples and principles.

Understanding the Patent

To begin, it is crucial to understand the specifics of the patent in question, including its title, abstract, claims, and descriptions. However, since the specific details of U.S. Patent 6,143,524 are not provided, we will use a hypothetical example and general principles.

Claim Analysis

Claim Construction

Claim construction is a critical step in understanding the scope and validity of a patent. This involves interpreting the language of the claims to determine what is covered by the patent[4].

  • Literal Meaning: The claims should be interpreted based on their literal meaning, taking into account the specification and the prosecution history of the patent.
  • Intrinsic Evidence: The specification, drawings, and prosecution history are considered intrinsic evidence that can help clarify the meaning of claim terms.
  • Extrinsic Evidence: While extrinsic evidence like dictionaries and expert testimony can be used, it should be approached with caution to avoid misinterpretation, as seen in the case where the Board erred by relying solely on an outdated IEEE dictionary[2].

Obviousness Determinations

Obviousness is a key factor in determining the validity of a patent. The USPTO and courts use the "expansive and flexible approach" to assessing obviousness, as outlined in cases like KSR Int’l Co. v. Teleflex, Inc.[2].

  • Motivation to Combine: The question is whether a person of ordinary skill in the art would have been motivated to combine the references in the manner claimed. This requires a reasonable likelihood of success and not absolute success[2].

Patent Landscape Analysis

Saturated Patent Spaces

Patent landscape analysis helps in understanding the saturation level of a specific technology area. This is crucial for advising on the potential rewards or risks of entering that space[3].

  • Competitor Analysis: Identifying key competitors and their patent portfolios can provide insights into the market dynamics and potential barriers to entry.
  • Technology Trends: Analyzing the trends over time can help in identifying areas of high saturation and potential opportunities for innovation.

Patentability Search vs. Patent Landscape Analysis

While a patentability search focuses on specific prior art related to the claims of a new filing, a full patent landscape analysis provides a broader view of the entire technology area[3].

  • High-Level Approach: This comprehensive approach helps in making long-term decisions about technology development and identifying areas where patent saturation is high, indicating the need to pivot to newer inventive spaces.

Strategic Insights from Patent Landscape Analysis

Identifying Gaps and Opportunities

A thorough patent landscape analysis can uncover gaps in the existing technology and identify opportunities for innovation.

  • Abandoned Technologies: Analyzing abandoned technologies can reveal areas where previous efforts were unsuccessful, providing valuable lessons for future research and development[3].

Monitoring Competitors

Tracking the patent activities of competitors is essential for staying competitive in the market.

  • Top Patent Owners: Identifying the top patent owners in a specific technology area can help in understanding the market leaders and their strategies[3].

Economic and Legal Implications

Patent Values and Litigation

Understanding the economic value of patents and the litigation landscape is crucial for strategic decision-making.

  • Patent Values: The value of a patent can be estimated based on renewal choices, citation dynamics, and economic growth. Technologies with higher revenue flows at grant time often experience faster depreciation of patent values[5].
  • Litigation Data: Access to detailed patent litigation data can provide insights into the frequency and outcomes of patent disputes, helping in risk assessment and strategy development[5].

Inter Partes Review (IPR) and Patent Trial and Appeal Board (PTAB)

IPR and PTAB processes are significant in challenging patent validity.

  • Challenging Patents: These processes are often faster and less expensive than judicial proceedings and require a lower burden of proof to invalidate patents. This makes them a preferred route for challenging patent validity[4].

Key Takeaways

  • Claim Construction: Accurate interpretation of claim language is critical for determining patent scope and validity.
  • Obviousness Determinations: The "expansive and flexible approach" to obviousness assessments is key in evaluating patent validity.
  • Patent Landscape Analysis: This provides a comprehensive view of the technology area, helping in strategic decision-making and identifying opportunities and risks.
  • Competitor Monitoring: Tracking competitors' patent activities is essential for staying competitive.
  • Economic and Legal Considerations: Understanding patent values and litigation data is vital for strategic planning.

FAQs

What is the purpose of a patent landscape analysis?

A patent landscape analysis is conducted to provide a comprehensive view of the patents and technologies within a specific area. It helps in identifying market trends, competitor activities, and potential opportunities or risks, guiding long-term R&D and business decisions.

How does the USPTO determine obviousness in patent claims?

The USPTO uses an "expansive and flexible approach" to assessing obviousness, considering whether a person of ordinary skill in the art would have been motivated to combine the references in the manner claimed. This approach is guided by cases like KSR Int’l Co. v. Teleflex, Inc.[2].

What is the difference between a patentability search and a patent landscape analysis?

A patentability search focuses on specific prior art related to the claims of a new filing, while a patent landscape analysis provides a broader view of the entire technology area, helping in identifying high saturation levels and potential opportunities for innovation[3].

Why is monitoring competitors' patent activities important?

Monitoring competitors' patent activities helps in understanding market dynamics, identifying potential barriers to entry, and staying competitive by aligning your R&D and business strategies with market trends.

What role do IPR and PTAB play in patent validity challenges?

IPR and PTAB processes allow for challenging patent validity in a faster and less expensive manner compared to judicial proceedings. They require a lower burden of proof to invalidate patents, making them a preferred route for entities threatened with or sued for patent infringement[4].

Sources

  1. Department of Energy, "hfto-2021-patent-analysis.pdf" - Pacific Northwest National Laboratory.
  2. IPWatchdog, "Examining USPTO Director Review Decisions in the Second Half of 2024".
  3. AcclaimIP, "Patent Landscape Analysis - Uncovering Strategic Insights".
  4. Congressional Research Service, "The Patent Trial and Appeal Board and Inter Partes Review".
  5. USPTO, "Working papers and book chapters - USPTO".

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Details for Patent 6,143,524

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Wyeth Pharmaceuticals Inc. NEUMEGA oprelvekin For Injection 103694 November 25, 1997 ⤷  Subscribe 2011-02-06
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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