CLINICAL TRIALS PROFILE FOR ACETIC ACID

All Clinical Trials for ACETIC ACID

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00116454 ↗	Trial for Hepatocellular Carcinoma Adjuvant Treatment by Lipiocis	Completed	ANRS, Emerging Infectious Diseases	Phase 3	2005-07-01	The recurrence of hepatocellular carcinoma (HCC), two years after curative treatment is high, about 40% - 50%. Recently, it has been shown that intra-arterial radioactive lipiodol (Lipiocis®) could reduce the recurrence of cancer and increase the survival after resection of HCC developed on cirrhosis B. The aim of the present trial is to investigate the effect of Lipiocis® in preventing recurrence after curative treatment of HCC in patients with viral or alcoholic hepatitis related cirrhosis by surgical or percutaneous ablation.
NCT00044213 ↗	Trial to Assess Chelation Therapy (TACT)	Completed	National Center for Complementary and Integrative Health (NCCIH)	Phase 3	2003-09-01	The purpose of this study is to determine the safety and effectiveness of ethylene diamine tetra-acetic (EDTA) chelation therapy in individuals with coronary artery disease.
NCT00044213 ↗	Trial to Assess Chelation Therapy (TACT)	Completed	National Heart, Lung, and Blood Institute (NHLBI)	Phase 3	2003-09-01	The purpose of this study is to determine the safety and effectiveness of ethylene diamine tetra-acetic (EDTA) chelation therapy in individuals with coronary artery disease.
NCT00044213 ↗	Trial to Assess Chelation Therapy (TACT)	Completed	Mt. Sinai Medical Center, Miami	Phase 3	2003-09-01	The purpose of this study is to determine the safety and effectiveness of ethylene diamine tetra-acetic (EDTA) chelation therapy in individuals with coronary artery disease.
NCT00051545 ↗	Seocalcitol Versus Placebo in the Adjuvant Treatment of Hepatocellular Carcinoma	Terminated	LEO Pharma	Phase 3	1999-11-01	To evaluate the efficacy of Seocalcitol in prolonging time to relapse following intended curative resection or percutaneous ablative treatment, i.e. percutaneous ethanol injection(s), percutaneous acetic acid injection(s), percutaneous microwave coagulation therapy, or percutaneous radiofrequency ablation for hepatocellular carcinoma (HCC).
NCT00003697 ↗	Dimethylxanthenone Acetic Acid in Treating Patients With Solid Tumors	Completed	University of Glasgow	Phase 1	1995-10-01	RATIONALE: Dimethylxanthenone acetic acid may stop the growth of cancer cells by stopping blood flow to the tumor. PURPOSE: Phase I trial to study the effectiveness of dimethylxanthenone acetic acid in treating patients with solid tumors that have not responded to previous therapy.

Clinical Trial Conditions for ACETIC ACID

Condition Name

Condition Name for ACETIC ACID
Intervention	Trials
Unspecified Adult Solid Tumor, Protocol Specific	3
Cervical Cancer	3
Type 2 Diabetes Mellitus	2
Skin Fibrosis	2

Condition MeSH

Condition MeSH for ACETIC ACID
Intervention	Trials
Neoplasms	5
Carcinoma	4
Uterine Cervical Neoplasms	4
Diabetes Mellitus	4

Clinical Trial Locations for ACETIC ACID

Trials by Country

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Trials by Country for ACETIC ACID
Location	Trials
United States	51
Egypt	9
Canada	8
Italy	7
United Kingdom	5

Trials by US State

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Trials by US State for ACETIC ACID
Location	Trials
California	6
Texas	5
New York	4
New Jersey	3
Minnesota	3

Clinical Trial Progress for ACETIC ACID

Clinical Trial Phase

Clinical Trial Phase for ACETIC ACID
Clinical Trial Phase	Trials
Phase 4	10
Phase 3	6
Phase 2/Phase 3	4

Clinical Trial Status

Clinical Trial Status for ACETIC ACID
Clinical Trial Phase	Trials
Completed	36
Unknown status	11
Recruiting	8

Clinical Trial Sponsors for ACETIC ACID

Sponsor Name

Sponsor Name for ACETIC ACID
Sponsor	Trials
National Cancer Institute (NCI)	7
M.D. Anderson Cancer Center	4
Digna Biotech S.L.	3

Sponsor Type

Sponsor Type for ACETIC ACID
Sponsor	Trials
Other	98
Industry	15
NIH	10

Acetic Acid: Clinical Trials, Market Analysis, and Projections

Introduction

Acetic acid, a versatile and widely used chemical, is not only a crucial component in various industrial processes but also has significant medical applications. This article will delve into the current clinical trials involving acetic acid, its market analysis, and future projections.

Clinical Trials Involving Acetic Acid

Cervical Cancer Screening

One of the notable medical applications of acetic acid is in cervical cancer screening. A recent cohort study evaluated the performance of visual inspection with acetic acid and Lugol iodine as a triage method for detecting cervical precancerous lesions among HPV-positive women. This method is particularly relevant in areas with limited healthcare resources, as it is affordable, easy to use, and provides immediate results without the need for laboratory support[1].

Type 2 Diabetes Management

Acetic acid, the primary component of apple cider vinegar, is being investigated for its potential in managing type 2 diabetes. A clinical trial at Texas A&M University is examining the effect of commercially available apple cider vinegar supplements and liquid on blood glucose levels in healthy adults after consuming a high-carbohydrate meal. The trial aims to clarify the efficacy of acetic acid in reducing postprandial glycemia, a benefit that has shown promising but inconsistent results in previous studies[4].

Market Analysis of Acetic Acid

Global Market Size and Growth

The global acetic acid market is experiencing significant growth. As of 2023, the market size was estimated at USD 13.80 billion and is projected to grow at a CAGR of 7.6% from 2024 to 2030, reaching approximately USD 27 billion by 2033[2][5].

Regional Dominance

The Asia-Pacific region dominates the global acetic acid market, accounting for a substantial share of the revenue. This dominance is driven by the rapid industrialization, population growth, and increasing demand from industries such as textiles, packaging, and automotive. China is a major player in this region, with significant production capacity and high consumption levels[2][3][5].

Key Industries and Applications

Acetic acid is a critical building block for the manufacture of multiple chemicals and is used in various industries, including plastics, rubber, inks, and textiles. The growing demand in these sectors, particularly in the pharmaceutical and food industries, is a key driver of the market growth. For instance, acetic acid is used in the production of medicinal tablets and as a food-grade ingredient in the food and beverage sector[2][3][5].

Market Projections

Future Growth and Trends

The acetic acid market is expected to continue its upward trend due to several factors:

• Technological Advancements: Innovations in production processes, such as methanol carbonylation, have improved efficiency and reduced costs, contributing to market growth[5].
• Sustainable Production: The development of bio-based acetic acid through the fermentation of biomass is gaining traction due to growing environmental concerns[5].
• Capacity Expansions: Major chemical companies are expanding their production capacities, especially in the Asia-Pacific region, to meet the rising global demand[5].

Challenges and Restraints

Despite the positive outlook, the acetic acid market faces several challenges:

• Fluctuating Feedstock Costs: Variations in the cost of raw materials can impact production costs and market dynamics.
• Environmental Concerns: Production processes for acetic acid can have environmental implications, and regulatory constraints may impede market growth[3].

Key Takeaways

• Clinical Trials: Acetic acid is being explored for its medical applications, including cervical cancer screening and type 2 diabetes management.
• Market Growth: The global acetic acid market is projected to grow significantly, driven by demand from various industries and technological advancements.
• Regional Dominance: The Asia-Pacific region, particularly China, is leading the market due to rapid industrialization and high consumption levels.
• Sustainability: The shift towards bio-based acetic acid production is expected to be a key trend in the future.

FAQs

What is the primary medical application of acetic acid being studied in clinical trials?

The primary medical applications include cervical cancer screening using visual inspection with acetic acid and Lugol iodine, and the management of type 2 diabetes through its effect on postprandial glycemia.

What is the projected growth rate of the global acetic acid market?

The global acetic acid market is projected to grow at a CAGR of 7.6% from 2024 to 2030 and at a CAGR of 6.20% from 2024 to 2033[2][5].

Which region dominates the global acetic acid market?

The Asia-Pacific region, particularly China, dominates the global acetic acid market due to rapid industrialization and high consumption levels[2][3][5].

What are the key drivers of the acetic acid market growth?

Key drivers include growing demand from industries such as plastics, textiles, and pharmaceuticals, technological advancements, and the shift towards sustainable production methods[2][3][5].

What challenges does the acetic acid market face?

The market faces challenges such as fluctuating feedstock costs, environmental concerns, and regulatory constraints[3].

Sources

1. Wang S, Dang L, Liu S, et al. Cervical Cancer Screening via Visual Inspection With Acetic Acid and Lugol Iodine for Triage of HPV-Positive Women. JAMA Netw Open. 2024;7(3):e244090. doi:10.1001/jamanetworkopen.2024.4090
2. Grand View Research. Acetic Acid Market Size, Share, Growth, Trends Report, 2030.
3. Market.us. Acetic Acid Market Size, Share | CAGR of 4.90%
4. Texas A&M University. Fall 2023: Clinical Trial Investigating Apple Cider Vinegar on Postprandial Blood Glucose.
5. The Brainy Insights. Acetic Acid Market Size to Reach USD 27 Billion by 2033, Says The Brainy Insights.