Treatment of Pediatric Hypertension With Altace Trial
Completed
Wyeth is now a wholly owned subsidiary of Pfizer
Phase 4
2002-07-01
Ramipril is an ACE inhibitor that has been marketed in the US for the treatment of
hypertension since 1991. It has been shown to be effective in reducing both systolic and
diastolic blood pressure in adults when used once daily. ACE inhibitors are frequently used
to treat hypertension in children, however ramipril has not been extensively tested in
children, and information regarding the efficacy and safety would therefore be of benefit to
children. This study is designed to demonstrate the efficacy and safety of ramipril in the
treatment of hypertension in children ages 6 through 16 years.
Treatment of Pediatric Hypertension With Altace Trial
Completed
Pfizer
Phase 4
2002-07-01
Ramipril is an ACE inhibitor that has been marketed in the US for the treatment of
hypertension since 1991. It has been shown to be effective in reducing both systolic and
diastolic blood pressure in adults when used once daily. ACE inhibitors are frequently used
to treat hypertension in children, however ramipril has not been extensively tested in
children, and information regarding the efficacy and safety would therefore be of benefit to
children. This study is designed to demonstrate the efficacy and safety of ramipril in the
treatment of hypertension in children ages 6 through 16 years.
PROBE Investigation of the Safety & Efficacy of Telmisartan (Micardis®) vs Ramipril (Altace®) Using ABPM in HTN
Completed
Boehringer Ingelheim
Phase 4
2002-10-01
Demonstrate that telmisartan 80mg was at least as effective and possibly superior to ramipril
5mg & 10mg in lowering mean ambulatory DBP and SBP during the last 6 hrs of the 24-hr dosing
interval in mild-to-moderate hypertensives at the end of 8 and 14 week treatment phases.
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