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Last Updated: November 7, 2024

CLINICAL TRIALS PROFILE FOR AMIKIN


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All Clinical Trials for AMIKIN

Trial ID Title Status Sponsor Phase Start Date Summary
NCT02574130 ↗ Effect of Additional Nebulized Amikacin in Ventilator-Associated Pneumonia Caused by Gram Negative Bacteria Completed Thammasat University N/A 2015-07-01 The purpose of this study is to determine the cure rate from ventilator-associated pneumonia (VAP) caused by Gram negative bacteria when administering add on nebulized amikacin to intravenous antibiotics compared to intravenous antibiotics alone.
NCT03169114 ↗ Raja Isteri Pengiran Anak Saleha Appendicitis Treatment Without Operation Terminated Raja Isteri Pengiran Anak Saleha Hospital N/A 2017-11-01 The RIPASA score is a Clinical Prediction Rule (CPR) for the diagnosis of acute appendicitis. Since its inception in 2009, the RIPASA score has been validated in various population in healthcare institutions around the world and reported significantly higher sensitivity and specificity when compared to Alvarado score. RIPASA score ranges from 3 to 16.5 with those having a score of less than 7 having a low probability of acute appendicitis and those with a score of 7.5 having a high probability of acute appendicitis. There has been a trend in the past decade on non-operative management of early-uncomplicated acute appendicitis (EuAA) with antibiotic therapy. This antibiotic non-operative management strategy (AMS) has been reported to work in children, thus avoiding unnecessary emergency operation. In adults presenting with early-uncomplicated acute appendicitis, this management pathway is still uncertain and most randomized controlled trials (RCT) and meta-analysis have not been able to show significant benefit of AMS over surgery management strategy (SMS), partly due to variable treatment efficacy, high recurrence rate within a year and a lack of agreement of whom would constitute a group of EuAA. The working hypothesis of this study is that RIPASA score as a Clinical Prediction Rule, can determine a group of patients with a diagnosis of EuAA, based on the range of scores (RIPASA score 7.5 - 11.5), who will benefit from an AMS rather than SMS, leading to improve patients' outcomes through a significant reduction in negative appendicectomy rate, shorter length of hospital stay, reduce post-operative complications and changing physician behavior in managing this group of patients to an AMS rather than SMS and ultimately financial cost savings. The primary specific aim of this study is to compare AMS with SMS in patients with EuAA in a prospective non-inferiority RCT. Secondary specific aims are to determine the range of RIPASA score that can define a group of patients with EuAA, step 3 validation of RIPASA score as a valid CPR and improve patient outcomes in terms of reducing unnecessary negative appendicectomy rate, hospital stay and complications arising from such surgery, and ultimately financial cost savings.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for AMIKIN

Condition Name

Condition Name for AMIKIN
Intervention Trials
Appendicitis 1
Pneumonia, Ventilator-Associated 1
Surgery 1
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Condition MeSH

Condition MeSH for AMIKIN
Intervention Trials
Pneumonia, Ventilator-Associated 1
Pneumonia, Bacterial 1
Pneumonia 1
Appendicitis 1
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Clinical Trial Locations for AMIKIN

Trials by Country

Trials by Country for AMIKIN
Location Trials
Thailand 2
Brunei Darussalam 1
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Clinical Trial Progress for AMIKIN

Clinical Trial Phase

Clinical Trial Phase for AMIKIN
Clinical Trial Phase Trials
N/A 2
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Clinical Trial Status

Clinical Trial Status for AMIKIN
Clinical Trial Phase Trials
Completed 1
Terminated 1
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Clinical Trial Sponsors for AMIKIN

Sponsor Name

Sponsor Name for AMIKIN
Sponsor Trials
Thammasat University 1
Raja Isteri Pengiran Anak Saleha Hospital 1
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Sponsor Type

Sponsor Type for AMIKIN
Sponsor Trials
Other 2
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