The purpose of this study is to determine whether different types of antidepressant medicines
relieve back pain that has lasted at least six months on a daily basis. Study participants
will be assigned to treatment with either a antidepressant acting on the serotonin system in
the brain (fluoxetine), one acting on the noradrenaline system (desipramine, or to a control
medication not expected to relieve pain (benztropine). Each participant will be seen at least
nine times during their 12 weeks on medication. This is a phase 2/3, outpatient study.
The purpose of this study is to determine whether different types of antidepressant medicines
relieve back pain that has lasted at least six months on a daily basis. Study participants
will be assigned to treatment with either a antidepressant acting on the serotonin system in
the brain (fluoxetine), one acting on the noradrenaline system (desipramine, or to a control
medication not expected to relieve pain (benztropine). Each participant will be seen at least
nine times during their 12 weeks on medication. This is a phase 2/3, outpatient study.
Using Drug Augmentation to Treat Obsessive Compulsive Disorder Patients Who Did Not Respond to Previous Treatment
Completed
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Phase 4
2007-05-01
This will be a controlled, randomized, double-blind and double-dummy study on the treatment
augmentation strategy for obsessive compulsive disorder patients non-respondent to first line
pharmacological treatment. The investigators will compare: fluoxetine maintenance at maximum
dosage for additional 12 weeks; the association of fluoxetine with quetiapine; and the
association of fluoxetine with clomipramine.
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