A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas
Completed
City of Hope Medical Center
Phase 1
2010-08-01
RATIONALE: Genetically-modified neural stem cells (NSCs) that convert 5-fluorocytosine (5-FC)
into the chemotherapy agent 5-FU (fluorouracil) at sites of tumor in the brain may be an
effective treatment for glioma.
PURPOSE: This clinical trial studies genetically-modified NSCs and 5-FC in patients
undergoing surgery for recurrent high-grade gliomas.
Safety Study of Fluconazole in Combination With Flucytosine for the Treatment of Early Cryptococcal Infection
Terminated
Bausch Health Americas, Inc.
Phase 2
2013-09-01
The purpose of this study is to determine if treatment with two medicines in combination
(fluconazole and flucytosine) is safe as compared with one medicine alone (fluconazole) for
the treatment of an early infection with a fungus called cryptococcus.
Safety Study of Fluconazole in Combination With Flucytosine for the Treatment of Early Cryptococcal Infection
Terminated
Kenya Medical Research Institute
Phase 2
2013-09-01
The purpose of this study is to determine if treatment with two medicines in combination
(fluconazole and flucytosine) is safe as compared with one medicine alone (fluconazole) for
the treatment of an early infection with a fungus called cryptococcus.
Safety Study of Fluconazole in Combination With Flucytosine for the Treatment of Early Cryptococcal Infection
Terminated
National Institute of Neurological Disorders and Stroke (NINDS)
Phase 2
2013-09-01
The purpose of this study is to determine if treatment with two medicines in combination
(fluconazole and flucytosine) is safe as compared with one medicine alone (fluconazole) for
the treatment of an early infection with a fungus called cryptococcus.
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